Trackman Philip C
Boston University, Henry M. Goldman School of Dental Medicine, 700 Albany Street, W-201, Boston, MA 02118, United States.
Matrix Biol. 2016 May-Jul;52-54:7-18. doi: 10.1016/j.matbio.2016.01.001. Epub 2016 Jan 6.
Advances in the understanding of the biological roles of the lysyl oxidase family of enzyme proteins in bone structure and function are reviewed. This family of proteins is well-known as catalyzing the final reaction required for cross-linking of collagens and elastin. Novel emerging roles for these proteins in the phenotypic development of progenitor cells and in angiogenesis are highlighted and which point to enzymatic and non-enzymatic roles for this family in bone development and homeostasis and in disease. The explosion of interest in the lysyl oxidase family in the cancer field highlights the need to have a better understanding of the functions of this protein family in normal and abnormal connective tissue homeostasis at fundamental molecular and cellular levels including in mineralized tissues.
本文综述了对赖氨酰氧化酶家族酶蛋白在骨骼结构和功能中的生物学作用的理解进展。该蛋白家族以催化胶原蛋白和弹性蛋白交联所需的最终反应而闻名。这些蛋白在祖细胞表型发育和血管生成中的新出现作用得到了强调，这表明该家族在骨骼发育、内稳态和疾病中具有酶促和非酶促作用。癌症领域对赖氨酰氧化酶家族的兴趣激增，凸显了在基础分子和细胞水平上，包括在矿化组织中，更好地了解该蛋白家族在正常和异常结缔组织内稳态中的功能的必要性。
