Aghaei-Ghareh-Bolagh Behnaz, Mithieux Suzanne M, Weiss Anthony S
Molecular Bioscience, University of Sydney, NSW 2006, Australia; Charles Perkins Centre, University of Sydney, NSW 2006, Australia; Bosch Institute, University of Sydney, NSW 2006, Australia.
Molecular Bioscience, University of Sydney, NSW 2006, Australia; Charles Perkins Centre, University of Sydney, NSW 2006, Australia; Bosch Institute, University of Sydney, NSW 2006, Australia.
Curr Opin Biotechnol. 2016 Jun;39:56-60. doi: 10.1016/j.copbio.2015.12.020. Epub 2016 Jan 15.
The elastomeric proteins elastin and resilin have been used extensively in the fabrication of biomaterials for tissue engineering applications due to their unique mechanical and biological properties. Tropoelastin is the soluble monomer component of elastin. Tropoelastin and resilin are both highly elastic with high resilience, substantial extensibility, high durability and low energy loss, which makes them excellent candidates for the fabrication of elastic tissues that demand regular and repetitive movement like the skin, lung, blood vessels, muscles and vocal folds. Combinations of these proteins with silk fibroin further enhance their biomechanical and biological properties leading to a new class of protein alloy materials with versatile properties. In this review, the properties of tropoelastin-based and resilin-based biomaterials with and without silk are described in concert with examples of their applications in tissue engineering.
弹性蛋白和节肢弹性蛋白等弹性体蛋白因其独特的机械和生物学特性，已被广泛用于制造组织工程应用的生物材料。原弹性蛋白是弹性蛋白的可溶性单体成分。原弹性蛋白和节肢弹性蛋白都具有高弹性、高回弹性、显著的延展性、高耐久性和低能量损失，这使其成为制造需要定期重复运动的弹性组织（如皮肤、肺、血管、肌肉和声带）的理想材料。这些蛋白质与丝素蛋白的组合进一步增强了它们的生物力学和生物学特性，从而产生了一类具有多种特性的新型蛋白质合金材料。在这篇综述中，结合基于原弹性蛋白和节肢弹性蛋白的生物材料（有无丝素蛋白）在组织工程中的应用实例，描述了它们的特性。
