基于弹性体重组蛋白的生物材料。
Elastomeric Recombinant Protein-based Biomaterials.
作者信息
Annabi Nasim, Mithieux Suzanne M, Camci-Unal Gulden, Dokmeci Mehmet R, Weiss Anthony S, Khademhosseini Ali
机构信息
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, 02139, USA ; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA ; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, 02139, USA.
出版信息
Biochem Eng J. 2013 Aug 15;77:110-118. doi: 10.1016/j.bej.2013.05.006.
Elastomeric protein-based biomaterials, produced from elastin derivatives, are widely investigated as promising tissue engineering scaffolds due to their remarkable properties including substantial extensibility, long-term stability, self-assembly, high resilience upon stretching, low energy loss, and excellent biological activity. These elastomers are processed from different sources of soluble elastin such as animal-derived soluble elastin, recombinant human tropoelastin, and elastin-like polypeptides into various forms including three dimensional (3D) porous hydrogels, elastomeric films, and fibrous electrospun scaffolds. Elastin-based biomaterials have shown great potential for the engineering of elastic tissues such as skin, lung and vasculature. In this review, the synthesis and properties of various elastin-based elastomers with their applications in tissue engineering are described.
由弹性蛋白衍生物制成的基于弹性蛋白的生物材料，因其具有显著特性，包括高延展性、长期稳定性、自组装性、拉伸时的高弹性、低能量损失和出色的生物活性，而被广泛研究作为有前景的组织工程支架。这些弹性体由不同来源的可溶性弹性蛋白加工而成，如动物源性可溶性弹性蛋白、重组人原弹性蛋白和弹性蛋白样多肽，并加工成各种形式，包括三维（3D）多孔水凝胶、弹性体薄膜和静电纺丝纤维支架。基于弹性蛋白的生物材料在皮肤、肺和血管等弹性组织工程中显示出巨大潜力。在这篇综述中，描述了各种基于弹性蛋白的弹性体的合成、特性及其在组织工程中的应用。
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