Bazzano L A, Hu T, Bertisch S M, Yao L, Harville E W, Gustat J, Chen W, Webber L S, Shu T, Redline S
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Pediatr Obes. 2016 Dec;11(6):535-542. doi: 10.1111/ijpo.12103. Epub 2016 Jan 19.
Obese adults have a higher risk of obstructive sleep apnoea (OSA); however, the relationship between childhood obesity and adult OSA risk is unclear. Objectives This study aimed to examine overweight/obesity (OW) in childhood and risk of OSA in middle age.
Childhood OW status was classified as never OW, weight cycling, persistent OW and incident OW. After 35 years of follow-up, high risk for OSA was determined by a positive score in ≥2 domains on the Berlin Questionnaire with obesity removed from scoring.
At initial assessment, mean (SD) age was 9.9 (2.9) years, and 23.9% were OW. Overall, 25.7% had scores indicating a high risk for OSA. Compared with participants who were never OW, those with persistent OW and incident OW were 1.36 (95%CI: 1.04-1.77) and 1.47 (1.11-1.96) times more likely to be high risk for OSA, after adjustment for multiple risk factors and adult OW status. Participants with an OW duration of 1-4 years, 5-8 years, and 8+ years were 0.96 (0.44-2.09), 1.20 (0.70-2.04) and 1.52 (1.22-1.90) times more likely to be high risk for OSA compared with those who were never OW (P for trend: 0.0002).
These results suggest that childhood OW is associated with a high risk of OSA in middle age.
肥胖成年人患阻塞性睡眠呼吸暂停（OSA）的风险更高；然而，儿童肥胖与成年后患OSA风险之间的关系尚不清楚。目的：本研究旨在探讨儿童期超重/肥胖（OW）与中年患OSA风险之间的关系。
儿童OW状态分为从未超重、体重波动、持续超重和新发超重。经过35年的随访，通过柏林问卷中≥2个领域的阳性评分确定OSA高风险，评分时排除肥胖因素。
在初始评估时，平均（标准差）年龄为9.9（2.9）岁，23.9%为超重。总体而言，25.7%的人得分表明有OSA高风险。与从未超重的参与者相比，在调整多个风险因素和成年期OW状态后，持续超重和新发超重的参与者患OSA高风险的可能性分别是其1.36倍（95%置信区间：1.04 - 1.77）和1.47倍（1.11 - 1.96）。超重持续时间为1 - 4年、5 - 8年和8年以上的参与者患OSA高风险的可能性分别是从未超重者的0.96倍（0.44 - 2.09）、1.20倍（0.70 - 2.04）和1.52倍（1.22 - 1.90）（趋势P值：0.0002）。
这些结果表明儿童期超重与中年患OSA的高风险相关。
