Hubert Patrice A, Lee Sang Gil, Lee Sun-Kyeong, Chun Ock K
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269-4017, USA.
Center on Aging, University of Connecticut Health Center, Farmington, CT 06030-5215, USA.
Antioxidants (Basel). 2014 Mar 11;3(1):144-58. doi: 10.3390/antiox3010144.
Bone loss during aging has become an increasing public health concern as average life expectancy has increased. One of the most prevalent forms of age-related bone disease today is osteoporosis in which the body slows down bone formation and existing bone is increasingly being resorbed by the body to maintain the calcium balance. Some causes of this bone loss can be attributed to dysregulation of osteoblast and osteoclast activity mediated by increased oxidative stress through the aging process. Due to certain serious adverse effects of the currently available therapeutic agents that limit their efficacy, complementary and alternative medicine (CAM) has garnered interest as a natural means for the prevention of this debilitating disease. Natural antioxidant supplementation, a type of CAM, has been researched to aid in reducing bone loss caused by oxidative stress. Naturally occurring polyphenols, such as anthocyanins rich in berries, are known to have anti-oxidative properties. Several studies have been reviewed to determine the impact polyphenol intake-particularly that of berries-has on bone health. Studies reveal a positive association of high berry intake and higher bone mass, implicating berries as possible inexpensive alternatives in reducing the risk of age related bone loss.
随着平均预期寿命的增加，衰老过程中的骨质流失已成为一个日益严重的公共卫生问题。当今与年龄相关的骨病最普遍的形式之一是骨质疏松症，在这种疾病中，身体减缓了骨形成，而现有的骨骼越来越多地被身体吸收以维持钙平衡。这种骨质流失的一些原因可归因于成骨细胞和破骨细胞活性的失调，这是由衰老过程中氧化应激增加介导的。由于目前可用的治疗药物存在某些严重的不良反应，限制了它们的疗效，补充和替代医学（CAM）作为预防这种使人衰弱疾病的天然手段而受到关注。天然抗氧化剂补充剂作为一种补充和替代医学，已被研究用于帮助减少由氧化应激引起的骨质流失。天然存在的多酚，如富含浆果的花青素，已知具有抗氧化特性。已对多项研究进行了综述，以确定多酚摄入量，特别是浆果的多酚摄入量对骨骼健康的影响。研究表明，大量摄入浆果与更高的骨量呈正相关，这意味着浆果可能是降低与年龄相关骨质流失风险的廉价替代品。
