微小RNA在肝细胞癌中的功能及临床潜力
Function and clinical potential of microRNAs in hepatocellular carcinoma.
作者信息
Wang Lijuan, Yue Yongfang, Wang Xian, Jin Hongchuan
机构信息
Department of Hematology, Hematology Laboratory, Linyi People's Hospital, Shandong University, Linyi, Shandong 276003, P.R. China.
Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, Medical School of Zhejiang University, Hangzhou, Zhejiang 310000, P.R. China.
出版信息
Oncol Lett. 2015 Dec;10(6):3345-3353. doi: 10.3892/ol.2015.3759. Epub 2015 Sep 29.
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs involved in the initiation and progression of several types of human cancer, including hepatocellular carcinoma (HCC), which is one of the most common types of cancer and the third leading cause of cancer-related mortality worldwide. Mounting evidence has demonstrated that miRNAs play a vital role in HCC, hepatitis, alcoholic liver disease, liver cell development and the metabolic functions of the liver. The aim of the present review was to summarize the most recent findings on the functions of miRNAs in the liver and discuss their potential roles in the diagnosis, prognosis and treatment of HCC.
摘要
微小RNA（miRNA）是一类小的非编码RNA，参与多种类型人类癌症的发生和发展，包括肝细胞癌（HCC），肝细胞癌是最常见的癌症类型之一，也是全球癌症相关死亡的第三大主要原因。越来越多的证据表明，miRNA在肝细胞癌、肝炎、酒精性肝病、肝细胞发育及肝脏代谢功能中发挥着至关重要的作用。本综述的目的是总结miRNA在肝脏功能方面的最新研究发现，并探讨它们在肝细胞癌诊断、预后及治疗中的潜在作用。
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