Huan Lin, Liang Lin-Hui, He Xiang-Huo
Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Cancer Biol Med. 2016 Dec;13(4):407-425. doi: 10.20892/j.issn.2095-3941.2016.0071.
Liver cancer, primarily hepatocellular carcinoma (HCC), is a major cause of cancer-related death worldwide. HCC is a suitable model of inflammation-induced cancer because more than 90% of HCC cases are caused by liver damage and chronic inflammation. Several inflammatory response pathways, such as NF-κB and JAK/STAT3 signaling pathways, play roles in the crosstalk between inflammation and HCC. MicroRNAs (miRNAs) are evolutionarily conserved, short endogenous, non-coding single-stranded RNAs that are involved in various biological and pathological processes by regulating gene expression and protein translation. Evidence showed that miRNAs play a pivotal role in hepatitis virus infection and serve as promoters or inhibitors of inflammatory response. Aberrant miRNA was observed during liver inflammation and HCC. Many dysregulated miRNAs modulate the initiation and progression of inflammation-induced HCC. This review summarizes the role and functions of miRNAs in inflammation-associated HCC, as well as the designed therapeutics targeting miRNAs to treat liver inflammation and HCC.
肝癌，主要是肝细胞癌（HCC），是全球癌症相关死亡的主要原因。HCC是炎症诱导癌症的合适模型，因为超过90%的HCC病例是由肝损伤和慢性炎症引起的。几种炎症反应途径，如NF-κB和JAK/STAT3信号通路，在炎症与HCC的相互作用中发挥作用。微小RNA（miRNA）是进化上保守的、短的内源性非编码单链RNA，通过调节基因表达和蛋白质翻译参与各种生物学和病理过程。证据表明，miRNA在肝炎病毒感染中起关键作用，并作为炎症反应的促进剂或抑制剂。在肝脏炎症和HCC期间观察到miRNA异常。许多失调的miRNA调节炎症诱导的HCC的发生和发展。本综述总结了miRNA在炎症相关HCC中的作用和功能，以及针对miRNA治疗肝脏炎症和HCC的设计疗法。
