中东呼吸综合征冠状病毒感染中的病毒脱落与环境清洁
Viral Shedding and Environmental Cleaning in Middle East Respiratory Syndrome Coronavirus Infection.
作者信息
Song Joon Young, Cheong Hee Jin, Choi Min Joo, Jeon Ji Ho, Kang Seong Hee, Jeong Eun Ju, Yoon Jin Gu, Lee Saem Na, Kim Sung Ran, Noh Ji Yun, Kim Woo Joo
机构信息
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.; Asian Pacific Influenza Institute (APII), Korea University College of Medicine, Seoul, Korea.; Infection Control Unit, Korea University Guro Hospital, Seoul, Korea.
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.; Asian Pacific Influenza Institute (APII), Korea University College of Medicine, Seoul, Korea.
出版信息
Infect Chemother. 2015 Dec;47(4):252-5. doi: 10.3947/ic.2015.47.4.252. Epub 2015 Dec 30.
Abstract
Viral shedding lasted 31 and 19 days from symptom onset in two patients with east respiratory syndrome coronavirus (MERS-CoV) pneumonia, respectively. Environmental real-time RT-PCR was weakly positive for bed guardrail and monitors. Even after cleaning the monitors with 70% alcohol-based disinfectant, RT-PCR was still weakly positive, and converted to negative only after wiping with diluted sodium chlorite. Further studies are required to clarify the appropriate methods to clean environments during and after treatment of patients with MERS-CoV infection.
摘要
中东呼吸综合征冠状病毒（MERS-CoV）肺炎的两名患者病毒排出分别从症状出现起持续了31天和19天。床护栏和监护仪的环境实时逆转录聚合酶链反应（RT-PCR）呈弱阳性。即使使用70%酒精基消毒剂清洁监护仪后，RT-PCR仍呈弱阳性，仅在用稀释的亚氯酸钠擦拭后才转为阴性。需要进一步研究以明确在MERS-CoV感染患者治疗期间及之后清洁环境的合适方法。
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本文引用的文献
1
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Infect Chemother. 2015 Jun;47(2):120-2. doi: 10.3947/ic.2015.47.2.120. Epub 2015 Jun 30.
2
Imported case of MERS-CoV infection identified in China, May 2015: detection and lesson learned.中国 2015 年 5 月报告输入性中东呼吸综合征冠状病毒感染病例：检测与经验教训。
Euro Surveill. 2015 Jun 18;20(24):21158. doi: 10.2807/1560-7917.es2015.20.24.21158.
3
Middle East respiratory syndrome.中东呼吸综合征
Lancet. 2015 Sep 5;386(9997):995-1007. doi: 10.1016/S0140-6736(15)60454-8. Epub 2015 Jun 3.
4
Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description.医院内中东呼吸综合征冠状病毒暴发：血清学、流行病学及临床描述
Clin Infect Dis. 2014 Nov 1;59(9):1225-33. doi: 10.1093/cid/ciu359. Epub 2014 May 14.
5
MERS coronavirus: data gaps for laboratory preparedness.MERS 冠状病毒：实验室准备的数据空白。
J Clin Virol. 2014 Jan;59(1):4-11. doi: 10.1016/j.jcv.2013.10.030. Epub 2013 Nov 7.
6
Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions.不同环境条件下中东呼吸综合征冠状病毒（MERS-CoV）的稳定性。
Euro Surveill. 2013 Sep 19;18(38):20590. doi: 10.2807/1560-7917.es2013.18.38.20590.
7
Hospital outbreak of Middle East respiratory syndrome coronavirus.医院中东呼吸综合征冠状病毒暴发。
N Engl J Med. 2013 Aug 1;369(5):407-16. doi: 10.1056/NEJMoa1306742. Epub 2013 Jun 19.
8
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