Simeoni Luca, Thurm Christoph, Kritikos Andreas, Linkermann Andreas
Otto-von-Guericke University, Institute of Molecular and Clinical Immunology , Magdeburg , Germany.
Clinic for Nephrology and Hypertension , Christian-Albrechts-University Kiel , Germany.
Clin Kidney J. 2016 Feb;9(1):1-10. doi: 10.1093/ckj/sfv135. Epub 2015 Dec 13.
The redox equilibrium is crucial for the maintenance of immune homeostasis. Here, we summarize recent data showing that oxidation regulates T-cell functions and that alterations of the redox equilibrium may play an important role in the pathogenesis of inflammatory conditions affecting the kidneys. We further discuss potential links between oxidation, T cells and renal diseases such as systemic lupus erythematosus, renal ischaemia/reperfusion injury, end-stage renal disease and hypertension. The basic understanding of oxidation as a means by which diseases are directly affected results in unexpected pathophysiological similarities. Finally, we describe potential therapeutic options targeting redox systems for the treatment of nephropathies affecting humans.
氧化还原平衡对于维持免疫稳态至关重要。在此，我们总结近期数据，这些数据表明氧化作用调节T细胞功能，且氧化还原平衡的改变可能在影响肾脏的炎症性疾病发病机制中发挥重要作用。我们还将进一步讨论氧化、T细胞与系统性红斑狼疮、肾脏缺血/再灌注损伤、终末期肾病和高血压等肾脏疾病之间的潜在联系。对氧化作为直接影响疾病的一种方式的基本理解揭示了意外的病理生理相似性。最后，我们描述了针对氧化还原系统治疗人类肾病的潜在治疗选择。
