Cheng Juanjuan, Ma Tingyun, Liu Wei, Wang Hanxue, Jiang Jizong, Wei Yue, Tian Hemiao, Zou Nan, Zhu Yudan, Shi Hailian, Cheng Xuemei, Wang Changhong
Institute of Chinese Materia Medica, The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai,, 201203, China.
Shanghai R&D Center for Standardization of Chinese Medicines, 199 Guoshoujing Road, Shanghai,, 201210, China.
BMC Complement Altern Med. 2016 Jan 22;16:20. doi: 10.1186/s12906-016-0999-y.
Compound Muniziqi granule (MNZQ), a traditional Uighur medicinal preparation, comprises 13 species of medicinal plants. MNZQ is traditionally used for regulating body immunity, modulating inflammation and pain, detoxification, and inhibiting tumor growth. This study aims to scientifically evaluate the anti-inflammatory and analgesic activities of MNZQ, support its clinical use and further research with scientific evidence.
The analgesic activity of MNZQ was evaluated using hot plate test and acetic acid-induced abdominal writhing test. Acute inflammation was evaluated using xylene-induced ear edema and carrageenan-induced paw edema models, while chronic inflammation was evaluated using cotton pellet-induced granuloma model.
MNZQ exerted analgesic activities with a significant dose-dependent increase in latency in the hot plate test. The percentage inhibition suggested that MNZQ exhibited analgesic activities in the central nervous system. Meanwhile, MNZQ at 0.8, 2.4, and 7.2 g/kg strongly inhibited the acetic acid-induced writhing response by 25.22% (p < 0.01), 44.60% (p < 0.001), and 49.41% (p < 0.001), respectively. MNZQ also exerted analgesic activities in the peripheral nervous system. Moreover, MNZQ was demonstrated a significant anti-inflammatory effect against xylene-induced edema in a dose-dependent manner. The percentage inhibition was 22.24% (p < 0.01) at the highest dosage of 7.2 g/kg. MNZQ at 1.62 and 4.86 g/kg significantly reduced carrageenan-induced rat hind paw edema by 82.43% and 84.32% (p < 0.001), respectively, 1 h after injecting carrageenan, and the inhibitory effect lasted for 5 h. MNZQ also exerted a significant anti-inflammatory effect against cotton pellet-induced granuloma formation. MNZQ at 1.62 and 4.86 g/kg could inhibit granuloma formation by 17.07% and 17.60%, respectively, whereas the percentage inhibition of diclofenac was 33.12%.
The results obtained suggest that MNZQ possesses potential anti-inflammatory and analgesic activities. This study provides a scientific basis for the use of MNZQ in alleviating pain and treating inflammatory disorders.
复方木尼孜其颗粒（MNZQ）是一种传统维吾尔药制剂，由13种药用植物组成。传统上，MNZQ用于调节机体免疫力、调节炎症和疼痛、解毒以及抑制肿瘤生长。本研究旨在科学评估MNZQ的抗炎和镇痛活性，为其临床应用及进一步研究提供科学依据。
采用热板法和醋酸致小鼠扭体法评估MNZQ的镇痛活性。利用二甲苯致小鼠耳肿胀模型和角叉菜胶致大鼠足肿胀模型评估急性炎症，采用棉球致大鼠肉芽肿模型评估慢性炎症。
MNZQ在热板试验中表现出镇痛活性，潜伏期随剂量增加显著延长。抑制率表明MNZQ在中枢神经系统发挥镇痛作用。同时，0.8、2.4和7.2 g/kg的MNZQ分别使醋酸致小鼠扭体反应显著抑制25.22%（p < 0.01）、44.60%（p < 0.001）和49.41%（p < 0.001）。MNZQ在外周神经系统也发挥镇痛作用。此外，MNZQ对二甲苯所致耳肿胀有显著抗炎作用，呈剂量依赖性。最高剂量7.2 g/kg时抑制率为22.24%（p < 0.01）。注射角叉菜胶1小时后，1.62和4.86 g/kg的MNZQ分别使角叉菜胶致大鼠后足肿胀显著减轻82.43%和84.32%（p < 0.001），抑制作用持续5小时。MNZQ对棉球致大鼠肉芽肿形成也有显著抗炎作用。1.62和4.86 g/kg的MNZQ分别可抑制肉芽肿形成17.07%和17.60%，而双氯芬酸的抑制率为33.12%。
所得结果表明MNZQ具有潜在的抗炎和镇痛活性。本研究为MNZQ用于缓解疼痛和治疗炎症性疾病提供了科学依据。
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