Olsen L, Nielsen I K, Zachariassen A, Sederberg-Olsen J, Frimodt-Möller N
Department of Obstetrics and Gynaecology, Copenhagen County Hospitals, Herlev.
Dan Med Bull. 1989 Oct;36(5):486-7.
Single-dose versus conventional six-day therapy with sulfamethizole for asymptomatic urinary tract infection in pregnant women was investigated in a prospective, randomised open study. During a nine-month period 4,274 pregnant women were screened for significant bacteriuria, which was found in 123 (2.9%), of whom only five had symptoms of urinary tract infection. Seventy-nine of the patients had a second urine culture performed, revealing significant counts of the same bacteria in only 41. These 41 patients were randomly allocated to one of the two treatment groups. Control urine cultures one week and 4-6 weeks after start of treatment revealed the same cure rates of approximately 50% in both groups. Single-dose treatment is not inferior to conventional therapy; future study is needed to find the best single-dose regimen.
在一项前瞻性、随机开放研究中，对磺胺甲噻二唑单剂量疗法与传统六日疗法治疗孕妇无症状尿路感染进行了调查。在九个月的时间里，对4274名孕妇进行了显著菌尿筛查，发现123例（2.9%）有显著菌尿，其中只有5例有尿路感染症状。对79例患者进行了第二次尿培养，结果显示只有41例同一细菌计数显著。这41例患者被随机分配到两个治疗组之一。治疗开始后1周和4 - 6周的对照尿培养显示，两组的治愈率相近，均约为50%。单剂量治疗并不逊于传统疗法；未来需要开展研究以找到最佳单剂量方案。
