Whalley P J, Cunningham F G
Obstet Gynecol. 1977 Mar;49(3):262-5.
Asymptomatic bacteriuria was identified in 300 pregnant women prior to the 28th week of gestation. In one group of 200 women short-term treatment with either nitrofurantoin or sulfamethizole was given for 14 days, and in another group of 100 women continuous therapy with one of these drugs was given for the remainder of gestation. Weekly urine cultures were obtained from all the women. Of the women treated with short-term therapy, 65% were abacteriuric for the remainder of pregnancy following one course of therapy, 24% became abacteriuric but subsequently relapsed, 2% had reinfection after becoming abacteriuric, and 9% demonstrated no response. Following treatment with a second course of short-term therapy, another 19% of these women were cured for the remainder of their pregnancy, and 3.5% responded to a third course. In the continuous therapy group, 88% of the women became abacteriuric for the remainder of the gestation, 3% demonstrated relapse, 2% developed reinfection, and 7% had no response to the first drug given. These data demonstrate that short-term administration of antimicrobials, when combined with surveillance for recurrent bacteriuria, is effective for the management of the pregnant woman with asymptomatic bacteriuria.
在妊娠28周前对300名孕妇进行了无症状菌尿的鉴定。在一组200名妇女中，给予呋喃妥因或磺胺甲噻二唑短期治疗14天，在另一组100名妇女中，在妊娠剩余时间给予其中一种药物持续治疗。每周对所有妇女进行尿培养。在接受短期治疗的妇女中，65%在一个疗程后在妊娠剩余时间内无菌尿，24%变为无菌尿但随后复发，2%在变为无菌尿后再次感染，9%无反应。在接受第二个短期疗程治疗后，这些妇女中的另外19%在妊娠剩余时间内治愈，3.5%对第三个疗程有反应。在持续治疗组中，88%的妇女在妊娠剩余时间内变为无菌尿，3%复发，2%发生再次感染，7%对给予的第一种药物无反应。这些数据表明，抗菌药物的短期给药与复发性菌尿的监测相结合，对无症状菌尿孕妇的管理是有效的。
