Bailey R R, Peddie B A, Bishop V
N Z Med J. 1986 Jul 9;99(805):501-3.
Sixty consecutive pregnant women with asymptomatic (covert) bacteriuria detected between 16 and 30 weeks gestation were randomly allocated to treatment with either a single 600 mg dose or a standard five-day course of trimethoprim. Twenty-seven of 30 women were cured with a single dose. Six of these 27 women were reinfected later in the pregnancy. Twenty-four of 30 women treated with a five-day course of trimethoprim were cured, and five became reinfected later in the pregnancy. One women vomited the single dose. There were no detrimental effects on the outcome of the pregnancies. Single dose therapy should be considered as the treatment of choice for asymptomatic bacteriuria in pregnancy.
连续60例在妊娠16至30周期间检测出无症状（隐性）菌尿的孕妇被随机分配接受单次600毫克剂量治疗或标准的为期五天的甲氧苄啶疗程治疗。30名妇女中有27名单次给药治愈。这27名妇女中有6名在妊娠后期再次感染。接受为期五天甲氧苄啶疗程治疗的30名妇女中有24名治愈，5名在妊娠后期再次感染。1名妇女呕吐了单次剂量药物。对妊娠结局没有不利影响。单次剂量疗法应被视为妊娠无症状菌尿的首选治疗方法。
