Okland Tyler, Karimkhani Chante, Pederson Hannah, Boyers Lindsay N, Sawyer Mark D, Rove Kyle O, Kenny McCabe C, Steinberg Steven, Naghavi Mohsen, Dellavalle Robert P
University of Colorado School of Medicine, Aurora, Colorado, USA.
College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Int Braz J Urol. 2017 Mar-Apr;43(2):289-303. doi: 10.1590/S1677-5538.IBJU.2016.0047.
We sought to determine whether disease representation in the Cochrane Database of Systematic Reviews (CDSR) reflects disease burden, measured by the Global Burden of Disease (GBD) Study as disability-adjusted life-years (DALYs).
Two investigators performed independent assessment of ten men's health and urologic diseases (MHUDs) in CDSR for systematic review and protocol representation, which were compared with percentage of total 2010 DALYs for the ten conditions. Data were analyzed for correlation using Spearman rank analysis.
Nine of ten MHUDs were represented by at least one CDSR review. There was a poor and statistically insignificant positive correlation between CDSR representation and disease burden (rho = 0.42, p = 0.23). CDSR representation was aligned with disease burden for three conditions, greater than disease burden for one condition, and less than disease burden for six conditions.
These results yield high-quality estimates to inform future research prioritization for MHUDs. While prioritization processes are complex and multi-faceted, disease burden should be strongly considered. Awareness of research priority setting has the potential to minimize research disparities on a global scale.
我们试图确定Cochrane系统评价数据库（CDSR）中的疾病呈现是否反映了疾病负担，该疾病负担由全球疾病负担（GBD）研究以伤残调整生命年（DALYs）来衡量。
两名研究者对CDSR中十种男性健康和泌尿系统疾病（MHUDs）的系统评价和方案呈现进行了独立评估，并将其与这十种疾病在2010年DALYs总数中的占比进行比较。使用Spearman秩分析对数据进行相关性分析。
十种MHUDs中有九种至少有一篇CDSR综述。CDSR呈现与疾病负担之间存在较弱且无统计学意义的正相关（rho = 0.42，p = 0.23）。CDSR呈现与三种疾病的负担一致，一种疾病的呈现大于其疾病负担，六种疾病的呈现小于其疾病负担。
这些结果产生了高质量的估计，可为未来MHUDs的研究优先级提供参考。虽然优先级确定过程复杂且多方面，但应强烈考虑疾病负担。了解研究优先级设定有可能在全球范围内最大限度地减少研究差异。
