Yue Xuetian, Wu Lihua, Hu Wenwei
Rutgers Cancer Institute of New Jersey, Rutgers the State University of New Jersey, New Brunswick, NJ USA.
Rutgers Cancer Institute of New Jersey, Rutgers the State University of New Jersey, New Brunswick, NJ USA; First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Cancer Cell Microenviron. 2015;2(3). doi: 10.14800/ccm.877.
Leukemia inhibitory factor (LIF), a secreted cytokine, plays an important role in a wide array of biological processes including inducing differentiation of leukemia cell, inflammatory response, neuronal development, embryonic implantation, stem cell self-renewal and cancer progression, etc. LIF exerts its biological functions mainly through the activation and regulation of JAK/STAT3, AKT, EKR1/2 and mTOR signal pathways. The expression levels of LIF are regulated by many different factors under different conditions in different tissue/cell types. For example, estrogen and p53 are important regulators for the high LIF production in uterine tissues at the implantation stage. Hypoxia plays a critical role in LIF overexpression in solid tumors. Many cytokines, including IL-6, IL-1β, can also induce the LIF expression and production. In this review, we summarize the current understanding on the transcriptional regulation of LIF under various conditions.
白血病抑制因子（LIF）是一种分泌型细胞因子，在包括诱导白血病细胞分化、炎症反应、神经元发育、胚胎着床、干细胞自我更新和癌症进展等在内的一系列生物过程中发挥重要作用。LIF主要通过激活和调节JAK/STAT3、AKT、EKR1/2和mTOR信号通路发挥其生物学功能。在不同组织/细胞类型的不同条件下，LIF的表达水平受多种不同因素调节。例如，雌激素和p53是着床期子宫组织中LIF高表达的重要调节因子。缺氧在实体瘤中LIF的过表达中起关键作用。许多细胞因子，包括IL-6、IL-1β，也能诱导LIF的表达和产生。在本综述中，我们总结了目前对各种条件下LIF转录调控的认识。
