Park M, Choi J-S, Park S M, Lee J-Y, Jung H Y, Sohn B K, Kim S N, Kim D J, Kwon J S
Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea.
Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea.
Transl Psychiatry. 2016 Jan 26;6(1):e721. doi: 10.1038/tp.2015.215.
Internet gaming disorder (IGD) leading to serious impairments in cognitive, psychological and social functions has gradually been increasing. However, very few studies conducted to date have addressed issues related to the event-related potential (ERP) patterns in IGD. Identifying the neurobiological characteristics of IGD is important to elucidate the pathophysiology of this condition. P300 is a useful ERP component for investigating electrophysiological features of the brain. The aims of the present study were to investigate differences between patients with IGD and healthy controls (HCs), with regard to the P300 component of the ERP during an auditory oddball task, and to examine the relationship of this component to the severity of IGD symptoms in identifying the relevant neurophysiological features of IGD. Twenty-six patients diagnosed with IGD and 23 age-, sex-, education- and intelligence quotient-matched HCs participated in this study. During an auditory oddball task, participants had to respond to the rare, deviant tones presented in a sequence of frequent, standard tones. The IGD group exhibited a significant reduction in response to deviant tones compared with the HC group in the P300 amplitudes at the midline centro-parietal electrode regions. We also found a negative correlation between the severity of IGD and P300 amplitudes. The reduced amplitude of the P300 component in an auditory oddball task may reflect dysfunction in auditory information processing and cognitive capabilities in IGD. These findings suggest that reduced P300 amplitudes may be candidate neurobiological marker for IGD.
导致认知、心理和社会功能严重受损的网络游戏障碍（IGD）正逐渐增多。然而，迄今为止进行的研究中，很少有涉及IGD中与事件相关电位（ERP）模式相关问题的。识别IGD的神经生物学特征对于阐明这种疾病的病理生理学很重要。P300是用于研究大脑电生理特征的有用ERP成分。本研究的目的是调查IGD患者与健康对照者（HCs）在听觉Oddball任务期间ERP的P300成分的差异，并在识别IGD相关神经生理特征时检查该成分与IGD症状严重程度的关系。26名被诊断为IGD的患者和23名年龄、性别、教育程度和智商匹配的HCs参与了本研究。在听觉Oddball任务中，参与者必须对频繁出现的标准音调序列中呈现的罕见、异常音调做出反应。与HC组相比，IGD组在中线中央顶叶电极区域的P300波幅对异常音调的反应显著降低。我们还发现IGD严重程度与P300波幅之间存在负相关。听觉Oddball任务中P300成分波幅降低可能反映了IGD中听觉信息处理和认知能力的功能障碍。这些发现表明，P300波幅降低可能是IGD的候选神经生物学标志物。
