Tremblay Monique, Brisson Diane, Gaudet Daniel
Lipidology Unit, Community Genomic Medicine Center, Department of Medicine, Université de Montréal, Chicoutimi, Québec, Canada.
ECOGENE-21, Clinical and Translational Research Center, Chicoutimi, Québec, Canada.
Hypertens Res. 2016 Jun;39(6):467-74. doi: 10.1038/hr.2016.4. Epub 2016 Jan 28.
Despite the numerous common pathways connecting blood pressure regulation to somatostatin (SST) metabolism, the SST gene has never been seen as a significant blood pressure modulator. The aim of this study was to evaluate the association between a poly-T repeat sequence (rs34872250) in the promoter of the SST gene and blood pressure, according to the obesity status. We genotyped 1918 French-Canadian subjects from a founder population. Analyses were performed according to the length of the poly-T repeat sequence on both alleles and divided into two groups, the 13/13-13/14 group and the 13/15-13/16 group. The effect of age, gender, body mass index, antihypertensive drugs and diabetic status were considered. Systolic, diastolic and mean blood pressures are significantly higher among the 13/15-13/16 group in the whole sample (P<0.05). Whereas the differences remain significant in women, they turn to be non-significant when men are considered alone. The risk of hypertension is increased in the 13/15-13/16 group, particularly among overweight/obese subjects. Systolic blood pressure is significantly higher among overweight/obese carriers of the 13/15-13/16 alleles in the whole sample (P<0.001), in men (P=0.006) and in women (P=0.002), even after correction for age and antihypertensive drugs. These results suggest that the poly-T repeat sequence polymorphism in the promoter of the SST gene is associated with significant variations of blood pressure and could modulate the risk of hypertension, particularly among women.
尽管存在众多将血压调节与生长抑素（SST）代谢联系起来的共同途径，但SST基因从未被视为重要的血压调节因子。本研究的目的是根据肥胖状况评估SST基因启动子中的多聚T重复序列（rs34872250）与血压之间的关联。我们对来自一个奠基人群的1918名法裔加拿大受试者进行了基因分型。根据两个等位基因上多聚T重复序列的长度进行分析，并分为两组，即13/13 - 13/14组和13/15 - 13/16组。考虑了年龄、性别、体重指数、抗高血压药物和糖尿病状态的影响。在整个样本中，13/15 - 13/16组的收缩压、舒张压和平均血压显著更高（P<0.05）。虽然在女性中差异仍然显著，但单独考虑男性时差异变得不显著。13/15 - 13/16组患高血压的风险增加，尤其是在超重/肥胖受试者中。在整个样本中（P<0.001）、男性中（P = 0.006）和女性中（P = 0.002），即使在校正年龄和抗高血压药物后，13/15 - 13/16等位基因的超重/肥胖携带者的收缩压仍显著更高。这些结果表明，SST基因启动子中的多聚T重复序列多态性与血压的显著变化相关，并可能调节高血压风险，尤其是在女性中。
