Suzuki H, Matsumoto K
Second Department of Surgery, Mie University School of Medicine, Tsu, Japan.
Jpn J Surg. 1989 Jul;19(4):387-91. doi: 10.1007/BF02471617.
Although only a small proportion of patients with ulcerative colitis (UC) will develop cancer, colorectal carcinoma is still an important complication of UC. Traditionally, histopathological dysplasia has been used as a marker for colorectal carcinogenesis in patients with UC, however, wide within- and between-observer disagreements regarding the grading of dysplasia have become evident of late. Recently, mucin histochemistry, autoradiography and flow cytometric or static cytophotometric DNA analysis have been used for monitoring the development of colorectal carcinoma in patients with UC. A brief review of the recent literatures, however, has disclosed that the value of these modern techniques in the follow up surveillance of patients with UC of long standing is rather limited and that none of these measures should be used in isolation for the early detection of colorectal carcinoma arising in UC, or for selecting candidates for colectomy. Rather, the possible role of these modern techniques appears to be as a tool for elucidating the mechanism of colorectal carcinogenesis in patients with UC.
尽管只有一小部分溃疡性结肠炎（UC）患者会患癌，但结直肠癌仍是UC的一种重要并发症。传统上，组织病理学异型增生一直被用作UC患者结直肠癌发生的标志物，然而，近来观察者内部和观察者之间在异型增生分级方面存在的广泛分歧已变得明显。最近，黏液组织化学、放射自显影以及流式细胞术或静态细胞光度术DNA分析已被用于监测UC患者结直肠癌的发生。然而，对近期文献的简要回顾表明，这些现代技术在长期UC患者的随访监测中的价值相当有限，而且这些措施都不应单独用于早期检测UC中发生的结直肠癌，或用于选择结肠切除术的候选者。相反，这些现代技术的可能作用似乎是作为一种阐明UC患者结直肠癌发生机制的工具。
