Kanemitsu T, Koike A, Yamamoto S
Cancer. 1985 Sep 1;56(5):1094-8. doi: 10.1002/1097-0142(19850901)56:5<1094::aid-cncr2820560523>3.0.co;2-8.
Cell proliferation kinetics, using autoradiography, was investigated in 4 specimens of normal colonic mucosa, 11 cases of ulcerative colitis, 15 adenomas, and 17 advanced cancers of the large intestine. In the normal mucosa, the labeled cells were located only in the lower three fifths of the crypts, the so-called proliferation zone, and their labeling index was 11.7 +/- 4.0%. In the ulcerative colitis, the proliferation zones were remarkably extended toward the upper part of the crypts, and the mean labeling index was 20.5 +/- 9.4%. In the adenomatous polyps, labeling was seen in any part of the crypts, and abnormal proliferation patterns such as denseness, stratification, expansion, and budding of the labeled cells tended to increase in accordance with the degree of the histologic atypism. Their mean labeling index was 22.2 +/- 8.6%. However each labeling index of the polyps increased proportionally to their histologic atypism, from 15.2 +/- 8.1% in grade II to 30.1 +/- 9.9% in grade V. The mean labeling index of the cancers was 23.3 +/- 9.6%, and there was little difference in the labeling patterns of the malignant polyps and cancers. The proliferation patterns of the polyp and cancer were qualitatively different from those of the normal mucosa and the ulcerative colitis.
采用放射自显影术对4例正常结肠黏膜、11例溃疡性结肠炎、15例腺瘤以及17例晚期大肠癌组织标本的细胞增殖动力学进行了研究。在正常黏膜中，标记细胞仅位于隐窝下五分之三部分，即所谓的增殖区，其标记指数为11.7±4.0%。在溃疡性结肠炎中，增殖区显著向隐窝上部扩展，平均标记指数为20.5±9.4%。在腺瘤性息肉中，隐窝各部位均可见标记，且随着组织学异型性程度的增加，标记细胞的密集、分层、扩展及出芽等异常增殖模式有增多趋势。其平均标记指数为22.2±8.6%。然而，息肉的各标记指数与其组织学异型性成正比增加，从Ⅱ级的15.2±8.1%增至Ⅴ级的30.1±9.9%。癌组织的平均标记指数为23.3±9.6%，恶性息肉与癌组织的标记模式差异不大。息肉和癌组织的增殖模式在性质上与正常黏膜和溃疡性结肠炎不同。
