细胞黏附分子CD44在黏液表皮样癌中的表达及其与肿瘤行为的关系。
Expression of cell adhesion molecule CD44 in mucoepidermoid carcinoma and its association with the tumor behavior.
作者信息
Binmadi Nada, Elsissi Azza, Elsissi Nadia
机构信息
Department of Oral Diagnostic Sciences, King Abdulaziz University, P.O. Box: 80200, Jeddah, 21589, Saudi Arabia.
Oral Pathology Department, University of Mansoura, Mansoura, Egypt.
出版信息
Head Face Med. 2016 Jan 29;12:8. doi: 10.1186/s13005-016-0102-4.
BACKGROUND
The most common malignant salivary gland tumors that affect both adult and children is mucoepidermoid carcinoma. It usually affects both minor and major salivary glands but parotid gland is considering the most common site in which this tumor arises. CD44, a trans-membrane glycoprotein, is an adhesion molecule of cell surface that play a role in the connections between cell-cell and cell-matrix. Many malignant tumors express high levels of CD44, thus, CD44 may be used as an indicator of aggressive behavior of some human malignancy. We evaluate CD44 expression in different grades of mucoepidermoid carcinoma and determine whether expression of CD44 can be used to predict tumor aggressiveness.
METHODS
Fifteen cases of mucoepidermoid carcinoma were retrieved from the oral pathology archives and grouped according to the histological grade as well as the clinical behavior regarding metastases and/or recurrence. Tissue sections were immunohistochemically stained for CD44. CD44 staining was scored for intensity and proportion of cells stained.
RESULTS
A higher proportion of high-grade tumor tissues showed moderate or strong CD44 staining compared to low-grade tumors. Additionally, CD44 expression was stronger in tumors from patients with recurrences or metastases, but theses differences were not statistically significant.
CONCLUSION
Our result showed that mucoepidermoid carcinomas are immunohistochemistry positive to CD44 compare to normal. A trend of CD44 expression associated with different histological grading and aggressive behavior of this tumor.
背景
黏液表皮样癌是影响成人和儿童的最常见的涎腺恶性肿瘤。它通常累及小涎腺和大涎腺，但腮腺被认为是该肿瘤最常见的发生部位。CD44是一种跨膜糖蛋白，是细胞表面的黏附分子，在细胞间和细胞与基质的连接中起作用。许多恶性肿瘤表达高水平的CD44，因此，CD44可作为某些人类恶性肿瘤侵袭行为的指标。我们评估CD44在不同分级黏液表皮样癌中的表达，并确定CD44的表达是否可用于预测肿瘤的侵袭性。
方法
从口腔病理档案中检索出15例黏液表皮样癌病例，并根据组织学分级以及转移和/或复发的临床行为进行分组。组织切片进行CD44免疫组织化学染色。对CD44染色的强度和染色细胞比例进行评分。
结果
与低级别肿瘤相比，高级别肿瘤组织中显示中度或强CD44染色的比例更高。此外，复发或转移患者的肿瘤中CD44表达更强，但这些差异无统计学意义。
结论
我们的结果表明，与正常情况相比，黏液表皮样癌对CD44免疫组织化学呈阳性。CD44表达存在与该肿瘤不同组织学分级和侵袭行为相关的趋势。
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