对老派阿米什人中11号染色体短臂基因座与双相情感障碍基因之间连锁关系的重新评估。
Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish.
作者信息
Kelsoe J R, Ginns E I, Egeland J A, Gerhard D S, Goldstein A M, Bale S J, Pauls D L, Long R T, Kidd K K, Conte G
机构信息
Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, Maryland 20892.
出版信息
Nature. 1989 Nov 16;342(6247):238-43. doi: 10.1038/342238a0.
DOI:10.1038/342238a0
PMID:2682265
Abstract
Reanalysis of an Old Order Amish pedigree, to include several new individuals and two changes in clinical status, markedly reduces the probability of linkage between bipolar affective disorder and the Harvey-ras-1 oncogene and insulin loci on chromosome 11. This linkage can be excluded using a large lateral extension of the original Amish pedigree.
摘要
对一个老派阿米什人谱系进行重新分析，纳入了几个新个体以及临床状态的两处变化，这显著降低了双相情感障碍与11号染色体上的哈维 - ras - 1癌基因和胰岛素基因座之间连锁的可能性。利用原始阿米什人谱系的大幅横向扩展可以排除这种连锁关系。
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