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Atazanavir use and carotid intima media thickness progression in HIV: potential influence of bilirubin.阿扎那韦的使用与HIV患者颈动脉内膜中层厚度进展：胆红素的潜在影响
AIDS. 2016 Feb 20;30(4):672-4. doi: 10.1097/QAD.0000000000000970.
2
Association Between Atazanavir-Induced Hyperbilirubinemia and Cardiovascular Disease in Patients Infected with HIV.阿扎那韦诱导的高胆红素血症与 HIV 感染患者心血管疾病的关联。
J Am Heart Assoc. 2020 Oct 20;9(19):e016310. doi: 10.1161/JAHA.120.016310. Epub 2020 Sep 15.
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Brief Report: Hyperbilirubinemia Is Associated With a Decreased Risk of Carotid Atherosclerosis in HIV-Infected Patients on Virological Suppression.简报：在病毒学抑制的 HIV 感染患者中，高胆红素血症与颈动脉粥样硬化风险降低相关。
J Acquir Immune Defic Syndr. 2018 Dec 15;79(5):617-623. doi: 10.1097/QAI.0000000000001854.
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Association Between Bilirubin, Atazanavir, and Cardiovascular Disease Events Among People Living With HIV Across the United States.在美国，胆红素、阿扎那韦与 HIV 感染者心血管疾病事件之间的关联。
J Acquir Immune Defic Syndr. 2019 Aug 15;81(5):e141-e147. doi: 10.1097/QAI.0000000000002071.
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Inflammation investigated as a source of pharmacokinetic variability of atazanavir in AIDS Clinical Trials Group protocol A5224s.在艾滋病临床试验组A5224s方案中，炎症被作为阿扎那韦药代动力学变异性的一个来源进行研究。
Antivir Ther. 2018;23(4):345-351. doi: 10.3851/IMP3209.
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Two-year treatment with rosuvastatin reduces carotid intima-media thickness in HIV type 1-infected patients receiving highly active antiretroviral therapy with asymptomatic atherosclerosis and moderate cardiovascular risk.瑞舒伐他汀两年治疗可降低接受高效抗逆转录病毒治疗且患有无症状动脉粥样硬化和中度心血管风险的1型HIV感染患者的颈动脉内膜中层厚度。
AIDS Res Hum Retroviruses. 2013 Mar;29(3):547-56. doi: 10.1089/aid.2012.0015. Epub 2012 Oct 25.
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Impact of atazanavir-based HAART regimen on the carotid intima-media thickness of HIV-infected persons: a comparative prospective cohort.基于阿扎那韦的高效抗逆转录病毒治疗方案对 HIV 感染者颈动脉内膜中层厚度的影响：一项比较性前瞻性队列研究。
AIDS. 2010 Nov 27;24(18):2797-801. doi: 10.1097/QAD.0b013e328340a21f.
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Increased carotid intima-media thickness is not associated with T-cell activation nor with cytomegalovirus in HIV-infected never-smoker patients.在从未吸烟的HIV感染患者中，颈动脉内膜中层厚度增加与T细胞激活及巨细胞病毒均无关。
AIDS. 2015 Jan 28;29(3):287-93. doi: 10.1097/QAD.0000000000000539.
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Echolucency of the carotid artery intima-media complex and intima-media thickness have different cardiovascular risk factor relationships: the Women's Interagency HIV Study.颈动脉内膜中层复合体的回声透亮性与内膜中层厚度具有不同的心血管危险因素关系：女性机构间HIV研究。
J Am Heart Assoc. 2015 Feb 19;4(2):e001405. doi: 10.1161/JAHA.114.001405.
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Atherosclerosis is associated with multiple pathogenic mechanisms in HIV-infected antiretroviral-naive or treated individuals.动脉粥样硬化与 HIV 感染的未接受抗逆转录病毒治疗或经治个体中的多种致病机制有关。
AIDS. 2013 Jan 28;27(3):381-9. doi: 10.1097/QAD.0b013e32835abcc9.

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1
The physiology of bilirubin: health and disease equilibrium.胆红素的生理学：健康与疾病的平衡。
Trends Mol Med. 2023 Apr;29(4):315-328. doi: 10.1016/j.molmed.2023.01.007. Epub 2023 Feb 22.
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Association Between Bilirubin, Atazanavir, and Cardiovascular Disease Events Among People Living With HIV Across the United States.在美国，胆红素、阿扎那韦与 HIV 感染者心血管疾病事件之间的关联。
J Acquir Immune Defic Syndr. 2019 Aug 15;81(5):e141-e147. doi: 10.1097/QAI.0000000000002071.
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Conflicting effects of atazanavir therapy on atherosclerotic risk factors in stable HIV patients: A randomized trial of regimen switch to atazanavir.阿扎那韦治疗对稳定期HIV患者动脉粥样硬化危险因素的矛盾影响：一项转换为阿扎那韦治疗方案的随机试验
PLoS One. 2017 Oct 12;12(10):e0181993. doi: 10.1371/journal.pone.0181993. eCollection 2017.
4
Epidemiology of ischemic heart disease in HIV.HIV 相关缺血性心脏病的流行病学。
Curr Opin HIV AIDS. 2017 Nov;12(6):540-547. doi: 10.1097/COH.0000000000000410.
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Cardiovascular outcomes among HIV-infected veterans receiving atazanavir.感染 HIV 的退伍军人接受阿扎那韦治疗的心血管结局。
AIDS. 2017 Sep 24;31(15):2095-2106. doi: 10.1097/QAD.0000000000001594.
6
Atazanavir and Cardiovascular Risk Among Human Immunodeficiency Virus-Infected Patients: A Systematic Review.阿扎那韦与人类免疫缺陷病毒感染患者的心血管风险：一项系统评价。
Infect Dis Ther. 2016 Dec;5(4):473-489. doi: 10.1007/s40121-016-0132-z. Epub 2016 Sep 27.

本文引用的文献

1
A prospective, randomized clinical trial of antiretroviral therapies on carotid wall thickness.一项关于抗逆转录病毒疗法对颈动脉壁厚度影响的前瞻性随机临床试验。
AIDS. 2015 Sep 10;29(14):1775-83. doi: 10.1097/QAD.0000000000000762.
2
Changes in Inflammation and Immune Activation With Atazanavir-, Raltegravir-, Darunavir-Based Initial Antiviral Therapy: ACTG 5260s.基于阿扎那韦、拉替拉韦、达芦那韦的初始抗病毒治疗中炎症和免疫激活的变化：ACTG 5260研究
Clin Infect Dis. 2015 Aug 15;61(4):651-60. doi: 10.1093/cid/civ327. Epub 2015 Apr 22.
3
IL-6 and its receptors in coronary artery disease and acute myocardial infarction.白细胞介素 6 及其在冠状动脉疾病和急性心肌梗死中的受体。
Cytokine. 2013 Jun;62(3):395-400. doi: 10.1016/j.cyto.2013.03.020. Epub 2013 Apr 10.
4
Alkaline phosphatase, serum phosphate, and incident cardiovascular disease and total mortality in older men.血清碱性磷酸酶、血清磷酸盐与老年男性心血管疾病事件和全因死亡率的关系。
Arterioscler Thromb Vasc Biol. 2013 May;33(5):1070-6. doi: 10.1161/ATVBAHA.112.300826. Epub 2013 Feb 21.
5
Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin.吉尔伯特综合征、UGT1A1*28等位基因与心血管疾病风险：胆红素可能的保护作用及治疗应用
Atherosclerosis. 2008 May;198(1):1-11. doi: 10.1016/j.atherosclerosis.2008.01.001. Epub 2008 Mar 17.
6
Interrelationships among circulating interleukin-6, C-reactive protein, and traditional cardiovascular risk factors in women.女性循环白细胞介素-6、C反应蛋白与传统心血管危险因素之间的相互关系。
Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1668-73. doi: 10.1161/01.atv.0000029781.31325.66.
7
Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels.吉尔伯特综合征与缺血性心脏病：胆红素水平升高的保护作用
Atherosclerosis. 2002 Feb;160(2):449-56. doi: 10.1016/s0021-9150(01)00601-3.
8
Association of serum bilirubin concentration with risk of coronary artery disease.
Clin Chem. 2000 Nov;46(11):1723-7.
9
The role of carotid arterial intima-media thickness in predicting clinical coronary events.颈动脉内膜中层厚度在预测临床冠状动脉事件中的作用。
Ann Intern Med. 1998 Feb 15;128(4):262-9. doi: 10.7326/0003-4819-128-4-199802150-00002.

Atazanavir use and carotid intima media thickness progression in HIV: potential influence of bilirubin.

作者信息

Chow Dominic, Kohorn Lindsay, Souza Scott, Ndhlovu Lishomwa, Ando Akika, Kallianpur Kalpana J, Byron Mary Margaret, Baumer Yvonne, Keating Sheila, Shikuma Cecilia

机构信息

aHawaii Center for AIDS, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii, USA bBlood Systems Research Institute, Core Immunology Laboratory, Blood Systems Research Institute, San Francisco, CA, USA.

出版信息

AIDS. 2016 Feb 20;30(4):672-4. doi: 10.1097/QAD.0000000000000970.

DOI:10.1097/QAD.0000000000000970
PMID:26825035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4793954/
Abstract
摘要