Carrick Frederick Robert, Oggero Elena, Pagnacco Guido, Wright Cameron H G, Machado Calixto, Estrada Genco, Pando Alejandro, Cossio Juan C, Beltrán Carlos
Neurology, Carrick Institute, Cape Canaveral, FL, USA; Global Clinical Scholars Research Training Program (GCSRT), Harvard Medical School, Boston, MA, USA; Institute of Neurology and Neurosurgery, Havana, Cuba; Bedfordshire Centre for Mental Health Research, University of Cambridge, Cambridge, UK.
Neurology, Carrick Institute, Cape Canaveral, FL, USA; Electrical and Computer Engineering, University of Wyoming, Laramie, WY, USA.
Front Neurol. 2016 Jan 22;7:3. doi: 10.3389/fneur.2016.00003. eCollection 2016.
Eye-movement training (EMT) can induce altered brain activation and change the functionality of saccades with changes of the brain in general.
To determine if EMT would result in changes in quantitative electroencephalogram (qEEG) and NIH Stroke Scale (NIHSS) in patients suffering from acute middle cerebral artery (MCA) infarction. Our hypothesis is that there would be positive changes in qEEG and NIHSS after EMT in patients suffering from acute MCA ischemic stroke.
Double-blind randomized controlled trial.
Thirty-four subjects with acute MCA ischemic stroke treated at university affiliated hospital intensive care unit.
Subjects were randomized into a "control" group treated only with aspirin (125 mg/day) and a "treatment" group treated with aspirin (125 mg/day) and a subject-specific EMT.
Delta-alpha ratio, power ratio index, and the brain symmetry index calculated by qEEG and NIHSS.
There was strong statistical and substantive significant improvement in all outcome measures for the group of stroke patients undergoing EMT. Such improvement was not observed for the "control" group, and there were no adverse effects.
The addition of EMT to a MCA ischemic stroke treatment paradigm has demonstrated statistically significant changes in outcome measures and is a low cost, safe, and effective complement to standard treatment.
眼动训练（EMT）可诱发大脑激活改变，并总体上随着大脑变化改变扫视功能。
确定眼动训练是否会导致急性大脑中动脉（MCA）梗死患者的定量脑电图（qEEG）和美国国立卫生研究院卒中量表（NIHSS）发生变化。我们的假设是，急性MCA缺血性卒中患者接受眼动训练后，qEEG和NIHSS会出现积极变化。
双盲随机对照试验。
34名在大学附属医院重症监护病房接受治疗的急性MCA缺血性卒中患者。
受试者被随机分为仅接受阿司匹林（125毫克/天）治疗的“对照组”和接受阿司匹林（125毫克/天）及个体化眼动训练治疗的“治疗组”。
通过qEEG和NIHSS计算的δ-阿尔法比值、功率比指数和脑对称指数。
接受眼动训练的卒中患者组在所有观察指标上均有强烈的统计学显著和实质性显著改善。“对照组”未观察到此类改善，且无不良反应。
在MCA缺血性卒中治疗模式中加入眼动训练已证明在观察指标上有统计学显著变化，是对标准治疗的低成本、安全且有效的补充。
