Iqbal Naeem, Cho Eun Jin
Department of Chemistry and Applied Chemistry, Hanyang University , Ansan 426-791, Republic of Korea.
Department of Chemistry, Chung-Ang University , Seoul 156-756, Republic of Korea.
J Org Chem. 2016 Mar 4;81(5):1905-11. doi: 10.1021/acs.joc.5b02726. Epub 2016 Feb 16.
An efficient visible-light photocatalysis-based one-pot amide synthesis method was developed; visible-light irradiation of a mixture of an aldehyde, tert-butyl hydrogen peroxide, and N-chlorosuccinimide using a Ru(bpy)3Cl2 photocatalyst afforded an acid chloride, which subsequently reacted with amine to yield the corresponding amide. The reaction was used to synthesize moclobemide and a D3 receptor intermediate.
开发了一种基于高效可见光光催化的一锅法酰胺合成方法；使用Ru(bpy)₃Cl₂光催化剂对醛、叔丁基过氧化氢和N-氯代琥珀酰亚胺的混合物进行可见光照射，得到一种酰氯，该酰氯随后与胺反应生成相应的酰胺。该反应被用于合成吗氯贝胺和一种D3受体中间体。
