Zhu Kai, Li Jun, Wang Yulin, Lai Hao, Wang Chunsheng
Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Shanghai Institute of Cardiovascular Disease, Shanghai 200032, China.
Stem Cells Int. 2016;2016:1384658. doi: 10.1155/2016/1384658. Epub 2015 Dec 29.
Stem cell therapy has attracted increasing attention as a promising treatment strategy for cardiac repair in ischemic heart disease. Nanoparticles (NPs), with their superior physical and chemical properties, have been widely utilized to assist stem cell therapy. With the help of NPs, stem cells can be genetically engineered for enhanced paracrine profile. To further understand the fate and behaviors of stem cells in ischemic myocardium, imaging NPs can label stem cells and be tracked in vivo under multiple modalities. Besides that, NPs can also be used to enhance stem cell retention in myocardium. These facts have raised efforts on the development of more intelligent and multifunctional NPs for cellular application. Herein, an overview of the applications of NPs-assisted stem cell therapy is given. Key issues and future prospects are also critically addressed.
干细胞疗法作为缺血性心脏病心脏修复的一种有前景的治疗策略，已引起越来越多的关注。纳米颗粒（NPs）凭借其卓越的物理和化学性质，已被广泛用于辅助干细胞疗法。在NPs的帮助下，干细胞可通过基因工程改造以增强旁分泌特征。为了进一步了解干细胞在缺血心肌中的命运和行为，成像NPs可标记干细胞并在多种模式下进行体内追踪。除此之外，NPs还可用于增强干细胞在心肌中的滞留。这些事实促使人们努力开发更智能、多功能的NPs用于细胞应用。本文给出了NPs辅助干细胞疗法应用的概述。还对关键问题和未来前景进行了批判性探讨。
