巴拿马植物的美容特性筛选以及基于高效液相色谱法对具有抗氧化和紫外线B防护活性成分的鉴定。
Screening of Panamanian Plants for Cosmetic Properties, and HPLC-Based Identification of Constituents with Antioxidant and UV-B Protecting Activities.
作者信息
Guldbrandsen Niels, De Mieri Maria, Gupta Mahabir, Liakou Eleni, Pratsinis Harris, Kletsas Dimitris, Chaita Eliza, Aligiannis Nektarios, Skaltsounis Alexios-Leandros, Hamburger Matthias
机构信息
Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 40, CH-4056 Basel, Switzerland.
CIFLORPAN, College of Pharmacy, University of Panama, Apartado 0824-00172, Panama, Republic of Panama.
出版信息
Sci Pharm. 2014 Oct 15;83(1):177-90. doi: 10.3797/scipharm.1409-12. Print 2015 Jan-Mar.
A library of 600 taxonomically diverse Panamanian plant extracts was screened for DPPH scavenging and UV-B protective activities, and the methanolic extracts of Mosquitoxylum jamaicense, Combretum cacoucia, and Casearia commersionia were submitted to HPLC-based activity profiling. The compounds located in the active time windows were isolated and identified as gallic acid derivatives and flavonoids. Gallic acid methyl ester (3) and digallic acid derivatives (2, 6) showed the highest DPPH scavenging activity (<10 μg/mL), while protocatechuic acid (7) and isoquercitrin (10) exhibited the highest UV-B protective properties.
对一个包含600种分类学上不同的巴拿马植物提取物的文库进行了1,1-二苯基-2-苦基肼（DPPH）清除和紫外线B防护活性筛选，并将牙买加蚊母树、毛叶风车子和康氏嘉赐树的甲醇提取物进行基于高效液相色谱的活性图谱分析。在活性时间窗口中定位的化合物被分离出来，并鉴定为没食子酸衍生物和黄酮类化合物。没食子酸甲酯（3）和双没食子酸衍生物（2、6）表现出最高的DPPH清除活性（<10μg/mL），而原儿茶酸（7）和异槲皮苷（10）表现出最高的紫外线B防护性能。
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