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冻干苹果皮对糖尿病大鼠心脏心室肌细胞电活动及组织的作用

The Actions of Lyophilized Apple Peel on the Electrical Activity and Organization of the Ventricular Syncytium of the Hearts of Diabetic Rats.

作者信息

Martínez-Ladrón de Guevara Elideth, Pérez-Hernández Nury, Villalobos-López Miguel Ángel, Pérez-Ishiwara David Guillermo, Salas-Benito Juan Santiago, Martínez Martínez Alejandro, Hernández-García Vicente

机构信息

Institute of Biomedical Sciences, Autonomous University of Ciudad Juárez, 32310 Ciudad Juárez, CHIH, Mexico.

National School of Medicine and Homeopathy, National Polytechnic Institute, 07320 Mexico City, DF, Mexico.

出版信息

J Diabetes Res. 2016;2016:8178936. doi: 10.1155/2016/8178936. Epub 2015 Dec 29.

DOI:10.1155/2016/8178936
PMID:26839897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4709627/
Abstract

This study was designed to examine the effects of lyophilized red delicious apple peel (RDP) on the action potentials (APs) and the input resistance-threshold current relationship. The experiments were performed on isolated papillary heart muscles from healthy male rats, healthy male rats treated with RDP, diabetic male rats, and diabetic male rats treated with RDP. The preparation was superfused with oxygenated Tyrode's solution at 37°C. The stimulation and the recording of the APs, the input resistance, and the threshold current were made using conventional electrophysiological methods. The RDP presented no significant effect in normal rats. Equivalent doses in diabetic rats reduced the APD and ARP. The relationship between input resistance and threshold current established an inverse correlation. The results indicate the following: (1) The functional structure of the cardiac ventricular syncytium in healthy rats is heterogeneous, in terms of input resistance and threshold current. Diabetes further accentuates the heterogeneity. (2) As a consequence, conduction block occurs and increases the possibility of reentrant arrhythmias. (3) These modifications in the ventricular syncytium, coupled with the increase in the ARP, are the adequate substrate so that, with diabetes, the heart becomes more arrhythmogenic. (4) RDP decreases the APD, the ARP, and most syncytium irregularity caused by diabetes.

摘要

本研究旨在考察冻干的红元帅苹果皮（RDP）对动作电位（APs）以及输入电阻-阈电流关系的影响。实验在来自健康雄性大鼠、用RDP处理的健康雄性大鼠、糖尿病雄性大鼠以及用RDP处理的糖尿病雄性大鼠的离体乳头肌上进行。标本在37℃用充氧的台氏液进行灌流。使用传统电生理方法对动作电位、输入电阻和阈电流进行刺激和记录。RDP对正常大鼠无显著影响。糖尿病大鼠中同等剂量的RDP可缩短动作电位时程（APD）和有效不应期（ARP）。输入电阻和阈电流之间的关系呈负相关。结果表明：（1）就输入电阻和阈电流而言，健康大鼠心室肌细胞间连接的功能结构是异质性的。糖尿病会进一步加剧这种异质性。（2）因此，会发生传导阻滞并增加折返性心律失常的可能性。（3）心室肌细胞间连接的这些改变，加上ARP的增加，是合适的基质，因此，糖尿病时心脏更容易发生心律失常。（4）RDP可缩短APD、ARP，并减少糖尿病引起的大多数心肌细胞间连接的不规则性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6340/4709627/c279ef5220d2/JDR2016-8178936.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6340/4709627/7cfe03ec3beb/JDR2016-8178936.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6340/4709627/7c5f70a9810f/JDR2016-8178936.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6340/4709627/87a9df7e0243/JDR2016-8178936.007.jpg
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本文引用的文献

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Phenolic Compounds in Apple (Malus x domestica Borkh.): Compounds Characterization and Stability during Postharvest and after Processing.苹果（苹果属苹果种）中的酚类化合物：采后及加工后的化合物表征与稳定性
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