Langworthy James, Parkman Henry P, Schey Ron
a Temple University Hospital , Department of Internal Medicine , Philadelphia , PA , USA.
b Temple University Hospital , Section of Gastroenterology , Philadelphia , PA , USA.
Expert Rev Gastroenterol Hepatol. 2016 Jul;10(7):817-25. doi: 10.1586/17474124.2016.1150175. Epub 2016 Mar 4.
Gastroparesis is a syndrome of delayed gastric emptying in the absence of mechanical obstruction. Symptoms can be debilitating, affect nutritional states, and significantly impact patients' quality of life. The management of these patients can prove quite difficult to many providers. This article will review the current management recommendations of gastroparesis, discuss investigational medications and interventions, and summarize future directions of therapies targeting the underlying disease process. Current therapies are subdivided into those improving gastric motility and those directly targeting symptoms. Non-pharmacologic interventions, including gastric stimulator implantation and intra-pyloric botulinum toxic injection are reviewed. A discussion of expert opinion in the field, a look into the future of gastroparesis management, and a key point summary conclude the article.
胃轻瘫是一种在无机械性梗阻情况下胃排空延迟的综合征。症状可能使人虚弱，影响营养状况，并显著影响患者的生活质量。对许多医疗服务提供者来说，管理这些患者可能颇具难度。本文将回顾胃轻瘫目前的管理建议，讨论研究性药物和干预措施，并总结针对潜在疾病过程的治疗未来方向。目前的治疗方法分为改善胃动力的方法和直接针对症状的方法。本文还将对包括胃刺激器植入和幽门内肉毒杆菌毒素注射在内的非药物干预措施进行综述。文章最后将讨论该领域的专家意见、展望胃轻瘫管理的未来，并进行要点总结。
