Tissue Engineering Research Group (TERG), Department of Anatomy, Royal College of Surgeons in Ireland (RSCI), 123, St. Stephens Green, Dublin 2, Dublin, D02 YN77, Ireland.
Trinity Center for Bioengineering (TCBE), Trinity College Dublin, Dublin 2, Dublin, Ireland.
Adv Mater. 2016 Jul;28(27):5648-61. doi: 10.1002/adma.201505349. Epub 2016 Feb 3.
Heart failure is a significant clinical issue. It is the cause of enormous healthcare costs worldwide and results in significant morbidity and mortality. Cardiac regenerative therapy has progressed considerably from clinical and preclinical studies delivering simple suspensions of cells, macromolecule, and small molecules to more advanced delivery methods utilizing biomaterial scaffolds as depots for localized targeted delivery to the damaged and ischemic myocardium. Here, regenerative strategies for cardiac tissue engineering with a focus on advanced delivery strategies and the use of multimodal therapeutic strategies are reviewed.
心力衰竭是一个重大的临床问题。它是全球医疗保健成本巨大的原因，并导致了大量的发病率和死亡率。心脏再生疗法已经从临床和临床前研究中简单的细胞、大分子和小分子悬浮液发展到了更先进的输送方法，利用生物材料支架作为受损和缺血性心肌局部靶向输送的储存库。在这里，我们重点介绍了先进的输送策略和多模式治疗策略在心脏组织工程中的再生策略。
