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Local axonal protection by WldS as revealed by conditional regulation of protein stability.
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Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons.
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SARM1 activation triggers axon degeneration locally via NAD⁺ destruction.
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Acquired axonal degeneration and regeneration: Recent insights and clinical correlations.
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Absence of SARM1 rescues development and survival of NMNAT2-deficient axons.
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Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury.
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Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening.
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Mechanisms of distal axonal degeneration in peripheral neuropathies.
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Pathological axonal death through a MAPK cascade that triggers a local energy deficit.
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Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.
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