Valent Peter, Groner Bernd, Schumacher Udo, Superti-Furga Giulio, Busslinger Meinrad, Kralovics Robert, Zielinski Christoph, Penninger Josef M, Kerjaschki Dontscho, Stingl Georg, Smolen Josef S, Valenta Rudolf, Lassmann Hans, Kovar Heinrich, Jäger Ulrich, Kornek Gabriela, Müller Markus, Sörgel Fritz
Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
J Innate Immun. 2016;8(2):111-20. doi: 10.1159/000443526. Epub 2016 Feb 5.
Translational research and precision medicine are based on a profound knowledge of cellular and molecular mechanisms contributing to various physiologic processes and pathologic reactions in diverse organs. Whereas specific molecular interactions and mechanisms have been identified during the past 5 decades, the underlying principles were defined much earlier and originate from to the seminal observations made by outstanding researchers between 1850 and 1915. One of the most outstanding exponents of these scientists is Paul Ehrlich. His work resulted not only in the foundation and birth of modern hematology and immunology, but also led to the development of chemotherapy and specific targeted treatment concepts. In 2015, the Medical University of Vienna organized a memorial meeting, with the aim of honoring Paul Ehrlich's contributions to science, and to commemorate the 100th anniversary of his death. The authors of the current review served as faculty members and dedicate this paper to Paul Ehrlich and his remarkable contributions to medicine.
转化医学和精准医学基于对细胞和分子机制的深入了解，这些机制促成了不同器官中的各种生理过程和病理反应。尽管在过去50年中已经确定了特定的分子相互作用和机制，但基本原理的定义要早得多，可追溯到1850年至1915年间杰出研究人员的开创性观察。这些科学家中最杰出的代表之一是保罗·埃尔利希。他的工作不仅奠定了现代血液学和免疫学的基础并使其诞生，还推动了化疗和特异性靶向治疗概念的发展。2015年，维也纳医科大学组织了一次纪念会议，旨在表彰保罗·埃尔利希对科学的贡献，并纪念他逝世100周年。本综述的作者作为教员，将本文献给保罗·埃尔利希及其对医学的卓越贡献。
