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威廉·科利：免疫疗法的先驱与之父。

William Coley: The Pioneer and the Father of Immunotherapy.

作者信息

Munir Mishaal, Cheema Asfand Yar, Ogedegbe Oboseh J, Aslam Muhammad Faisal, Kim San

机构信息

Medicine, Ghurki Trust and Teaching Hospital, Lahore, PAK.

Internal Medicine, Lahore Medical & Dental College, Lahore, PAK.

出版信息

Cureus. 2024 Sep 10;16(9):e69113. doi: 10.7759/cureus.69113. eCollection 2024 Sep.

DOI:10.7759/cureus.69113
PMID:39391466
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11466495/
Abstract

William Coley was an unacclaimed hero of early cancer treatment. His work is often overshadowed by more recent advancements in immunotherapy. Coley's innovative work in the 1910s and 1930s laid the groundwork for what would become a major field in oncology. His experiments with bacterial vaccines by making use of the immune system to combat cancer preceded contemporary immunotherapy for several decades. This review provides a comprehensive exploration of Coley's life, his groundbreaking research, the socio-scientific challenges he faced, and his lasting impact on cancer treatment. Even though he faced lots of initial resistance and challenges, Coley's work has influenced modern immunotherapy practices.

摘要

威廉·科利是早期癌症治疗领域一位默默无名的英雄。他的工作常常被免疫疗法的最新进展所掩盖。科利在20世纪10年代和30年代的创新性工作为肿瘤学这一重要领域奠定了基础。他利用免疫系统对抗癌症的细菌疫苗实验比当代免疫疗法早了几十年。这篇综述全面探讨了科利的生平、他的开创性研究、他所面临的社会科学挑战以及他对癌症治疗的持久影响。尽管最初面临诸多阻力和挑战，但科利的工作已经影响了现代免疫疗法实践。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09d9/11466495/776f43aa514f/cureus-0016-00000069113-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09d9/11466495/776f43aa514f/cureus-0016-00000069113-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09d9/11466495/776f43aa514f/cureus-0016-00000069113-i01.jpg

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本文引用的文献

1
The Evolution of Cancer Immunotherapy.癌症免疫疗法的演变
Vaccines (Basel). 2021 Jun 8;9(6):614. doi: 10.3390/vaccines9060614.
2
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications.癌症免疫疗法的历史与进展：了解肿瘤浸润免疫细胞的特征及其治疗意义。
Cell Mol Immunol. 2020 Aug;17(8):807-821. doi: 10.1038/s41423-020-0488-6. Epub 2020 Jul 1.
3
Talkin' Toxins: From Coley's to Modern Cancer Immunotherapy.谈毒素：从考莱毒素到现代癌症免疫疗法。
Toxins (Basel). 2020 Apr 9;12(4):241. doi: 10.3390/toxins12040241.
4
Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine.保罗·埃尔利希（1854 - 1915）及其对转化医学基础与诞生的贡献。
J Innate Immun. 2016;8(2):111-20. doi: 10.1159/000443526. Epub 2016 Feb 5.
5
The Treatment of Inoperable Sarcoma by Bacterial Toxins (the Mixed Toxins of the Streptococcus erysipelas and the Bacillus prodigiosus).用细菌毒素（丹毒链球菌和灵杆菌的混合毒素）治疗无法手术的肉瘤
Proc R Soc Med. 1910;3(Surg Sect):1-48.
6
II. Contribution to the Knowledge of Sarcoma.二、对肉瘤知识的贡献
Ann Surg. 1891 Sep;14(3):199-220. doi: 10.1097/00000658-189112000-00015.
7
The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas.威廉·B·科利毒素与骨和软组织肉瘤的治疗
Iowa Orthop J. 2006;26:154-8.
8
Dr William Coley and tumour regression: a place in history or in the future.威廉·科利医生与肿瘤消退：是历史中的一席之地还是未来的希望？
Postgrad Med J. 2003 Dec;79(938):672-80.
9
Clinical effect of Coley's toxin. II. A seven-year study.科利毒素的临床疗效。II. 一项为期七年的研究。
Cancer Chemother Rep. 1962 Aug;21:43-68.
10
Coley's toxin: historical perspective.科利毒素：历史回顾
Isr Med Assoc J. 2002 Jun;4(6):471-2.