Mahyari Saman, Mahyari Behnam, Emami Seyed Ahmad, Malaekeh-Nikouei Bizhan, Jahanbakhsh Seyedeh Pardis, Sahebkar Amirhossein, Mohammadpour Amir Hooshang
Pharmaceutical Research Center, Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahyari Dentistry Clinic, Iran Square, Neyshabour, Iran.
Complement Ther Clin Pract. 2016 Feb;22:93-8. doi: 10.1016/j.ctcp.2015.12.001. Epub 2015 Dec 10.
Gingivitis is a highly prevalent periodontal disease resulting from microbial infection and subsequent inflammation. The efficacy of herbal preparations in subjects with gingivitis has been reported in some previous studies.
To investigate the efficacy of a polyherbal mouthwash containing hydroalcoholic extracts of Zingiber officinale, Rosmarinus officinalis and Calendula officinalis (5% v/w) compared with chlorhexidine and placebo mouthwashes in subjects with gingivitis.
Sixty patients participated in this randomized double-blind placebo-controlled trial and were randomly assigned to the polyherbal mouthwash (n = 20), chlorhexidine mouthwash (n = 20) or placebo mouthwash (n = 20). Participants were instructed to use the mouthwash twice a day (after breakfast and dinner) for 30 s for a period of two weeks. Gingival and plaque indices were assessed using MGI, GBI and MQH scales at baseline, day 7 and day 14 of the trial.
There were significant improvements in all assessed efficacy measures i.e. MGI, GBI and MQH scores from baseline to the end of trial in both polyherbal and chlorhexidine mouthwash groups; however, the scores remained statistically unchanged in the placebo group. MGI, BGI and MQH scores in the treatment groups were significantly lower compared with those of the control group at both day 7 and day 14 of the trial. However, there was no significant difference between the polyherbal and chlorhexidine groups, neither at day 7 nor day 14 of the trial. Polyherbal mouthwash was safe and there was neither report of adverse reactions, nor any drop-out during the course of study.
Polyherbal mouthwash containing hydroalcoholic extracts of Z. officinale, R. officinalis and C. officinalis (5%) was effective in the treatment of gingivitis and its efficacy was comparable to that of chlorhexidine mouthwash.
牙龈炎是一种由微生物感染及随后的炎症引起的高度常见的牙周疾病。先前的一些研究报道了草药制剂对牙龈炎患者的疗效。
研究含有生姜、迷迭香和金盏花水醇提取物（5% v/w）的多草药漱口水与洗必泰漱口水和安慰剂漱口水相比，对牙龈炎患者的疗效。
60名患者参与了这项随机双盲安慰剂对照试验，并被随机分配至多草药漱口水组（n = 20）、洗必泰漱口水组（n = 20）或安慰剂漱口水组（n = 20）。参与者被指示每天使用漱口水两次（早餐和晚餐后），每次30秒，持续两周。在试验的基线、第7天和第14天，使用MGI、GBI和MQH量表评估牙龈和菌斑指数。
多草药漱口水组和洗必泰漱口水组从基线到试验结束时，所有评估的疗效指标即MGI、GBI和MQH评分均有显著改善；然而，安慰剂组的评分在统计学上保持不变。在试验的第7天和第14天，治疗组的MGI、BGI和MQH评分显著低于对照组。然而，在试验的第7天和第14天，多草药组和洗必泰组之间均无显著差异。多草药漱口水是安全的，在研究过程中既没有不良反应报告，也没有任何退出情况。
含有生姜、迷迭香和金盏花水醇提取物（5%）的多草药漱口水对牙龈炎治疗有效，其疗效与洗必泰漱口水相当。
