Department of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Agios Ioannis, 62110 Serres, Greece; Intensive Care Unit, 424 General Military Hospital of Thessaloniki, Thessaloniki, Greece.
Division of Sport and Exercise Sciences, Abertay University, Dundee, UK.
Free Radic Biol Med. 2016 Sep;98:2-12. doi: 10.1016/j.freeradbiomed.2016.02.005. Epub 2016 Feb 17.
The field of redox biology is inherently intertwined with oxidative stress biomarkers. Oxidative stress biomarkers have been utilized for many different objectives. Our analysis indicates that oxidative stress biomarkers have several salient applications: (1) diagnosing oxidative stress, (2) pinpointing likely redox components in a physiological or pathological process and (3) estimating the severity, progression and/or regression of a disease. On the contrary, oxidative stress biomarkers do not report on redox signaling. Alternative approaches to gain more mechanistic insights are: (1) measuring molecules that are integrated in pathways linking redox biochemistry with physiology, (2) using the exomarker approach and (3) exploiting -omics techniques. More sophisticated approaches and large trials are needed to establish oxidative stress biomarkers in the clinical setting.
氧化应激生物标志物与氧化还原生物学领域密切相关。氧化应激生物标志物已被用于许多不同的目的。我们的分析表明，氧化应激生物标志物具有几个突出的应用：（1）诊断氧化应激，（2）确定生理或病理过程中可能的氧化还原成分，（3）估计疾病的严重程度、进展和/或消退。相反，氧化应激生物标志物并不报告氧化还原信号。获得更多机制见解的替代方法是：（1）测量整合在将氧化还原生物化学与生理学联系起来的途径中的分子，（2）使用外显子标志物方法，（3）利用组学技术。需要更复杂的方法和大型试验来在临床环境中建立氧化应激生物标志物。
