Wang Ke, Li Dan, Sun Lu
Department of Gynecologic Cancer, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.
Onco Targets Ther. 2016 Jan 19;9:377-86. doi: 10.2147/OTT.S96309. eCollection 2016.
The aim of this study was to investigate the clinical significance and biological function of epidermal growth factor receptor (EGFR) expressed in tumor stroma of epithelial ovarian cancer.
Immunohistological staining of EGFR was evaluated in 242 patients with epithelial ovarian cancer. The correlations of EGFR expression in tumor stroma with clinicopathological features and with the expression level of Ki-67 were analyzed by SPSS software. Kaplan-Meier analysis and the Cox proportional hazard model were used to analyze the effect of EGFR expression in tumor stroma on the prognosis of patients with epithelial ovarian cancer. Meanwhile, the activities of proliferation and migration of tumor cells were detected when EGFR overexpressed in stroma cells.
EGFR expression in tumor stroma correlated significantly with clinical stage (χ (2)=7.002, P=0.008) and distant metastases (χ (2)=16.59, P<0.001). Furthermore, there was a significantly positive correlation between the level of EGFR expressed in tumor stroma and the level of Ki-67 expressed in tumor cells (χ (2)=6.120, P=0.013). Patients with high EGFR expression level in tumor stroma showed poor survival (P=0.002). Multivariate analysis showed that high expression of EGFR in tumor stroma was an independent predictor for epithelial ovarian cancer patients (hazard ratio =1.703; 95% confidence interval 1.125-2.578, P=0.012). Furthermore, stroma cells overexpressing EGFR could promote the proliferation and migration of adjacent tumor cells.
High expression of EGFR in tumor stroma correlates with aggressive clinical features in epithelial ovarian cancer, and is an independent prognostic factor.
本研究旨在探讨上皮性卵巢癌肿瘤基质中表达的表皮生长因子受体（EGFR）的临床意义及生物学功能。
对242例上皮性卵巢癌患者进行EGFR免疫组织化学染色评估。采用SPSS软件分析肿瘤基质中EGFR表达与临床病理特征及Ki-67表达水平的相关性。运用Kaplan-Meier分析和Cox比例风险模型分析肿瘤基质中EGFR表达对上皮性卵巢癌患者预后的影响。同时，检测基质细胞中EGFR过表达时肿瘤细胞的增殖和迁移活性。
肿瘤基质中EGFR表达与临床分期显著相关（χ(2)=7.002，P=0.008）及远处转移显著相关（χ(2)=16.59，P<0.001）。此外，肿瘤基质中EGFR表达水平与肿瘤细胞中Ki-67表达水平呈显著正相关（χ(2)=6.120，P=0.013）。肿瘤基质中EGFR表达水平高的患者生存率低（P=0.002）。多因素分析显示，肿瘤基质中EGFR高表达是上皮性卵巢癌患者的独立预测因素（风险比=1.703；95%置信区间1.125-2.578，P=0.012）。此外，过表达EGFR的基质细胞可促进相邻肿瘤细胞的增殖和迁移。
肿瘤基质中EGFR高表达与上皮性卵巢癌的侵袭性临床特征相关，是独立的预后因素。
