a School of Medicine , University of California-Davis , Sacramento , California , USA.
b Department of Dermatology , University of California-Davis , Sacramento , California , USA.
Crit Rev Food Sci Nutr. 2017 Nov 22;57(17):3632-3639. doi: 10.1080/10408398.2015.1137859.
Lactoferrin is a glycoprotein widely present in mammalian secretions and possesses documented protective effects, including antimicrobial and anti-inflammatory properties. While its therapeutic use is being investigated for a myriad of diseases, there is increasing interest in its application for skin disease. Our objective was to systematically review the clinical evidence for the use and efficacy of lactoferrin for the treatment of dermatological conditions. Pubmed and Embase databases were searched for clinical studies evaluating lactoferrin for dermatological conditions. A total of six studies were reviewed. Of the current clinical trials, there is encouraging evidence to suggest that lactoferrin may be beneficial in acne, psoriasis, and diabetic ulcerations. Although the current evidence is promising, further research is necessary to establish lactoferrin as complementary therapy in the clinical setting.
乳铁蛋白是一种广泛存在于哺乳动物分泌物中的糖蛋白，具有已被证实的保护作用，包括抗菌和抗炎特性。虽然其治疗用途正在被研究用于治疗多种疾病，但人们对其在皮肤病治疗中的应用越来越感兴趣。我们的目的是系统地综述乳铁蛋白在皮肤科疾病治疗中的应用和疗效的临床证据。在 Pubmed 和 Embase 数据库中搜索了评估乳铁蛋白治疗皮肤科疾病的临床研究。共审查了六项研究。在目前的临床试验中，有令人鼓舞的证据表明乳铁蛋白可能对痤疮、银屑病和糖尿病溃疡有益。尽管目前的证据很有前景，但仍需要进一步的研究来确定乳铁蛋白在临床环境中的补充治疗作用。
