Li Fan, Huang Hui, Song Ligong, Hao Hua, Ying Mingzhong
The International Medical Center of the People's Liberation Army General Hospital, District 3, Division 2, 28 Fuxin Road, Beijing 100853, China.
J Clin Med Res. 2016 Mar;8(3):220-4. doi: 10.14740/jocmr2409w. Epub 2016 Jan 26.
The influences of obstructive sleep apnea hypopnea syndrome (OSAHS) on blood pressure and C-reactive protein (CRP) were observed, and the underlying mechanism was investigated.
Respiratory sleep monitoring was performed on 188 male patients who were newly diagnosed with hypertension. Based on the apnea hypopnea index (AHI) results, patients were divided into a normal control group (AHI ≤ 5, n = 35), a mild OSAHS group (5 < AHI ≤ 15, n = 28), a moderate OSAHS group (15 < AHI ≤ 30, n = 57), and a severe OSAHS group (AHI > 30, n = 68). Ambulatory blood pressure monitoring was conducted on patients in each group, and blood samples were collected to detect indicators, including fasting blood glucose (FBG), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and high-sensitivity CRP (hs-CRP).
TG and hs-CRP in patients in the moderate and severe OSAHS groups were higher than those in the normal control group (P < 0.01, P < 0.05). Additionally, their mean nocturnal systolic blood pressure (nSBP) and nocturnal diastolic blood pressure (nDBP) were higher than those in the normal control group (P < 0.01, P < 0.05). However, the percentage of blood pressure reduction at night was significantly lower than that in the normal control group (P < 0.01). AHI and hs-CRP positively correlated with nSBP (adjusted R(2) = 0.46) and nDBP (adjusted R(2) = 0.38) and negatively correlated with the nocturnal blood pressure reduction percentage (adjusted R(2) = 0.48).
Moderate and severe OSAHS induced increases in nocturnal blood pressure and CRP content in the body, resulting in further damage to the circadian rhythms of blood pressure.
观察阻塞性睡眠呼吸暂停低通气综合征（OSAHS）对血压及C反应蛋白（CRP）的影响，并探讨其潜在机制。
对188例新诊断为高血压的男性患者进行呼吸睡眠监测。根据呼吸暂停低通气指数（AHI）结果，将患者分为正常对照组（AHI≤5，n = 35）、轻度OSAHS组（5＜AHI≤15，n = 28）、中度OSAHS组（15＜AHI≤30，n = 57）和重度OSAHS组（AHI＞30，n = 68）。对每组患者进行动态血压监测，并采集血样检测指标，包括空腹血糖（FBG）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和高敏CRP（hs-CRP）。
中度和重度OSAHS组患者的TG和hs-CRP高于正常对照组（P＜0.01，P＜0.05）。此外，其夜间平均收缩压（nSBP）和夜间舒张压（nDBP）高于正常对照组（P＜0.01，P＜0.05）。然而，夜间血压下降百分比明显低于正常对照组（P＜0.01）。AHI和hs-CRP与nSBP（调整R² = 0.46）和nDBP（调整R² = 0.38）呈正相关，与夜间血压下降百分比呈负相关（调整R² = 0.48）。
中度和重度OSAHS导致夜间血压及体内CRP含量升高，进一步损害血压昼夜节律。
