非酒精性脂肪性肝病（NAFLD）与健康相关生活质量（HRQOL）受损有关。
Non-alcoholic Fatty Liver Disease (NAFLD) is associated with impairment of Health Related Quality of Life (HRQOL).
作者信息
Golabi Pegah, Otgonsuren Munkhzul, Cable Rebecca, Felix Sean, Koenig Aaron, Sayiner Mehmet, Younossi Zobair M
机构信息
Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, USA.
Center For Liver Disease, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA, USA.
出版信息
Health Qual Life Outcomes. 2016 Feb 9;14:18. doi: 10.1186/s12955-016-0420-z.
BACKGROUND
NAFLD impacts patient reported outcomes (PROs). Our aim was to assess the impact of NAFLD on patients' HRQOL.
METHODS
National Health and Nutrition Examination Survey (NHANES) 2001-2011 data were used to identify adult patients with NAFLD [Fatty Liver Index (FLI) > 60 in absence of other liver disease and excessive alcohol >20 g/day for men, >10 g/day for women]. Patients with other chronic diseases (ex. HIV, cancer, end-stage kidney disease) were excluded. Subjects without any of these conditions were healthy controls. HCV RNA (+) patients were HCV-controls. All patients completed NHANES HRQOL-4 questionnaire. Linear regression determined the association between NAFLD and HRQOL components adjusting for age, gender, race, and BMI.
RESULTS
Participants with complete data were included (n = 9661); 3333 NAFLD (age 51 years and BMI 34 kg/m(2)); 346 HCV+ (age 49 years; BMI 27 kg/m(2)) and 5982 healthy controls (age 48 years and BMI 26 kg/m(2)). The proportion of subjects rating their health as "fair" or "poor" in descending order were HCV controls (30 %) NAFLD (20 %) and healthy controls (10 %) (p < 0.001). HRQOL-4 components scores 2-4 were lowest for HCV, followed by NAFLD and then healthy controls (p-values p = 0.011 to < .0001). After adjustment for age, gender, race, and BMI, NAFLD patients were 18-20 % more likely to report days when their physical health wasn't good or were unable to perform daily activities as a result (p < .0001).
CONCLUSIONS
NAFLD causes impairment of HRQOL. As NAFLD is becoming the most important cause of CLD, its clinical and PRO impact must be assessed.
背景
非酒精性脂肪性肝病（NAFLD）会影响患者报告结局（PROs）。我们的目的是评估NAFLD对患者健康相关生活质量（HRQOL）的影响。
方法
使用2001 - 2011年美国国家健康与营养检查调查（NHANES）数据来确定患有NAFLD的成年患者[在无其他肝脏疾病且男性每日饮酒量超过20克、女性超过10克的情况下，脂肪肝指数（FLI）> 60]。排除患有其他慢性疾病（如艾滋病毒、癌症、终末期肾病）的患者。没有这些疾病的受试者为健康对照。丙型肝炎病毒RNA（HCV RNA）阳性患者为HCV对照。所有患者均完成了NHANES HRQOL - 4问卷。线性回归确定了在调整年龄、性别、种族和体重指数（BMI）后NAFLD与HRQOL各成分之间的关联。
结果
纳入了具有完整数据的参与者（n = 9661）；3333例NAFLD患者（年龄51岁，BMI 34 kg/m²）；346例HCV阳性患者（年龄49岁；BMI 27 kg/m²）和5982例健康对照（年龄48岁，BMI 26 kg/m²）。将健康状况评为“一般”或“较差”的受试者比例从高到低依次为HCV对照（30%）、NAFLD患者（20%）和健康对照（10%）（p < 0.001）。HRQOL - 4各成分得分在2 - 4分的情况，HCV阳性患者最低，其次是NAFLD患者，然后是健康对照（p值为0.011至< 0.0001）。在调整年龄、性别、种族和BMI后，NAFLD患者报告身体健康不佳或因此无法进行日常活动天数的可能性要高出18% - 20%（p < 0.0001）。
结论
NAFLD会导致HRQOL受损。由于NAFLD正成为慢性肝病（CLD）的最重要病因，必须评估其临床和PRO影响。
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