De Sousa Karina P, Doolan Denise L
Infectious Diseases Programme,QIMR Berghofer Medical Research Institute,Herston,QLD 4029,Australia.
Parasitology. 2016 Feb;143(2):236-44. doi: 10.1017/S0031182015001079.
Immunomics is a relatively new field of research which integrates the disciplines of immunology, genomics, proteomics, transcriptomics and bioinformatics to characterize the host-pathogen interface. Herein, we discuss how rapid advances in molecular immunology, sophisticated tools and molecular databases are facilitating in-depth exploration of the immunome. In our opinion, an immunomics-based approach presides over traditional antigen and vaccine discovery methods that have proved ineffective for highly complex pathogens such as the causative agents of malaria, tuberculosis and schistosomiasis that have evolved genetic and immunological host-parasite adaptations over time. By using an integrative multidisciplinary approach, immunomics offers enormous potential to advance 21st century antigen discovery and rational vaccine design against complex pathogens such as the Plasmodium parasite.
免疫组学是一个相对较新的研究领域，它整合了免疫学、基因组学、蛋白质组学、转录组学和生物信息学等学科，以表征宿主与病原体的界面。在此，我们讨论分子免疫学的快速进展、精密工具和分子数据库如何促进对免疫组的深入探索。我们认为，基于免疫组学的方法优于传统的抗原和疫苗发现方法，事实证明，这些传统方法对于高度复杂的病原体（如疟疾、结核病和血吸虫病的病原体，它们随着时间的推移已经进化出了遗传和免疫方面的宿主-寄生虫适应性）是无效的。通过使用综合多学科方法，免疫组学为推进21世纪针对复杂病原体（如疟原虫）的抗原发现和合理疫苗设计提供了巨大潜力。
