Popadic Gacesa J, Schick F, Machann J, Grujic N
Laboratory for Functional Diagnostics, Department of Physiology, Medical School, University of Novi Sad, Novi Sad, Serbia.
Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany.
Clin Physiol Funct Imaging. 2017 Nov;37(6):558-566. doi: 10.1111/cpf.12346. Epub 2016 Feb 11.
This report provides an overview on the present knowledge on intramyocellular lipids (IMCL) and their dynamics in the course of interventions with physical activity of variable type and intensity in different population groups, as accessible by examinations using non-invasive volume-selective H magnetic resonance spectroscopy ( H MRS). IMCL serve as energy source in skeletal muscle for fat oxidation in the mitochondria and became intensively studied after discovery of their relation with insulin sensitivity. While baseline levels of IMCL concentration have been shown to be mainly dependent on the metabolic status (insulin sensitivity), on the level of training and on fibre composition in the muscles, studies applying different physical activity protocols revealed the dynamic of their depletion and replenishment. From the findings in human studies, it can be concluded that IMCL levels are potentially useful markers for monitoring metabolic adaptation of skeletal muscle to sportive activities and training.
本报告概述了目前关于肌内脂质（IMCL）的知识，以及在不同人群中进行不同类型和强度的体育活动干预过程中IMCL的动态变化，这些可通过使用非侵入性体积选择性氢磁共振波谱（1H MRS）检查获得。IMCL作为骨骼肌中脂肪在线粒体中氧化的能量来源，自发现其与胰岛素敏感性的关系后受到深入研究。虽然已表明IMCL浓度的基线水平主要取决于代谢状态（胰岛素敏感性）、训练水平和肌肉纤维组成，但应用不同体育活动方案的研究揭示了其消耗和补充的动态变化。从人体研究结果可以得出结论，IMCL水平可能是监测骨骼肌对体育活动和训练的代谢适应性的有用标志物。
