评价西洛芬净（LY121019）治疗兔实验性白色念珠菌心内膜炎的效果。
Evaluation of cilofungin (LY121019) for treatment of experimental Candida albicans endocarditis in rabbits.
作者信息
Padula A, Chambers H F
机构信息
Medical Service, San Francisco General Hospital, California.
出版信息
Antimicrob Agents Chemother. 1989 Oct;33(10):1822-3. doi: 10.1128/AAC.33.10.1822.
Abstract
The efficacy of cilofungin (LY121019) for aortic valve endocarditis caused by Candida albicans in rabbits was studied. Vegetation titers were similar for cilofungin-treated and untreated rabbits. No rabbit survived beyond 5 days in either group. All rabbits given amphotericin B survived, and titers were reduced. Cilofungin was ineffective in this model.
摘要
研究了西洛芬净（LY121019）对兔白色念珠菌所致主动脉瓣心内膜炎的疗效。西洛芬净治疗组和未治疗组的赘生物滴度相似。两组均无兔存活超过5天。所有给予两性霉素B的兔均存活，且滴度降低。在该模型中，西洛芬净无效。
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