O'Brien Kate M, Nonnenmann Matthew W
Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa, United States of America.
PLoS One. 2016 Feb 11;11(2):e0149083. doi: 10.1371/journal.pone.0149083. eCollection 2016.
The 2009 H1N1 pandemic emphasized a need to evaluate zoonotic transmission of influenza A in swine production. Airborne influenza A virus has been detected in swine facilities during an outbreak. However, the personal exposure of veterinarians treating infected swine has not been characterized. Two personal bioaerosol samplers, the NIOSH bioaerosol sampler and the personal high-flow inhalable sampler head (PHISH), were placed in the breathing zone of veterinarians treating swine infected with either H1N1 or H3N2 influenza A. A greater number of viral particles were recovered from the NIOSH bioaerosol sampler (2094 RNA copies/m3) compared to the PHISH sampler (545 RNA copies/m3). In addition, the majority of viral particles were detected by the NIOSH bioaerosol sampler in the >4 μm size fraction. These results suggest that airborne influenza A virus is present in the breathing zone of veterinarians treating swine, and the aerosol route of zoonotic transmission of influenza virus should be further evaluated among agricultural workers.
2009年甲型H1N1流感大流行凸显了评估猪生产中甲型流感人畜共患传播的必要性。在疫情爆发期间，猪舍中检测到了空气传播的甲型流感病毒。然而，治疗感染猪的兽医的个人暴露情况尚未得到描述。将两个个人生物气溶胶采样器，即美国国家职业安全与健康研究所（NIOSH）生物气溶胶采样器和个人高流量可吸入采样头（PHISH），放置在治疗感染H1N1或H3N2甲型流感猪的兽医的呼吸区内。与PHISH采样器（545个RNA拷贝/立方米）相比，从NIOSH生物气溶胶采样器中回收的病毒颗粒数量更多（2094个RNA拷贝/立方米）。此外，NIOSH生物气溶胶采样器在大于4微米的粒径范围内检测到了大多数病毒颗粒。这些结果表明，在治疗猪的兽医的呼吸区内存在空气传播的甲型流感病毒，并且应在农业工人中进一步评估流感病毒人畜共患传播的气溶胶途径。
