Quinlivan L, Cooper J, Davies L, Hawton K, Gunnell D, Kapur N
Centre for Mental Health and Safety, University of Manchester, Manchester, UK.
Institute of Population Health, University of Manchester, Manchester, UK.
BMJ Open. 2016 Feb 12;6(2):e009297. doi: 10.1136/bmjopen-2015-009297.
The aims of this review were to calculate the diagnostic accuracy statistics of risk scales following self-harm and consider which might be the most useful scales in clinical practice.
Systematic review.
We based our search terms on those used in the systematic reviews carried out for the National Institute for Health and Care Excellence self-harm guidelines (2012) and evidence update (2013), and updated the searches through to February 2015 (CINAHL, EMBASE, MEDLINE, and PsychINFO). Methodological quality was assessed and three reviewers extracted data independently. We limited our analysis to cohort studies in adults using the outcome of repeat self-harm or attempted suicide. We calculated diagnostic accuracy statistics including measures of global accuracy. Statistical pooling was not possible due to heterogeneity.
The eight papers included in the final analysis varied widely according to methodological quality and the content of scales employed. Overall, sensitivity of scales ranged from 6% (95% CI 5% to 6%) to 97% (CI 95% 94% to 98%). The positive predictive value (PPV) ranged from 5% (95% CI 3% to 9%) to 84% (95% CI 80% to 87%). The diagnostic OR ranged from 1.01 (95% CI 0.434 to 2.5) to 16.3 (95%CI 12.5 to 21.4). Scales with high sensitivity tended to have low PPVs.
It is difficult to be certain which, if any, are the most useful scales for self-harm risk assessment. No scales perform sufficiently well so as to be recommended for routine clinical use. Further robust prospective studies are warranted to evaluate risk scales following an episode of self-harm. Diagnostic accuracy statistics should be considered in relation to the specific service needs, and scales should only be used as an adjunct to assessment.
本综述旨在计算自伤后风险量表的诊断准确性统计数据,并考量哪些量表在临床实践中可能最为有用。
系统综述。
我们依据为英国国家卫生与临床优化研究所自伤指南(2012年)及证据更新(2013年)所开展的系统综述中使用的检索词,将检索更新至2015年2月(CINAHL、EMBASE、MEDLINE及PsychINFO)。评估方法学质量,三位评审员独立提取数据。我们将分析限于使用重复自伤或自杀未遂结果的成人队列研究。我们计算了包括整体准确性指标在内的诊断准确性统计数据。由于存在异质性,无法进行统计合并。
最终分析纳入的八篇论文在方法学质量及所采用量表的内容方面差异很大。总体而言,量表的敏感性范围为6%(95%置信区间5%至6%)至97%(95%置信区间94%至98%)。阳性预测值(PPV)范围为5%(95%置信区间3%至9%)至84%(95%置信区间80%至87%)。诊断比值比范围为1.01(95%置信区间0.434至2.5)至16.3(95%置信区间12.5至21.4)。敏感性高的量表往往阳性预测值较低。
难以确定哪些(如果有的话)是用于自伤风险评估的最有用量表。没有任何量表表现得足够好到可被推荐用于常规临床使用。有必要开展进一步有力的前瞻性研究以评估自伤事件后的风险量表。应结合具体服务需求考虑诊断准确性统计数据,且量表仅应用作评估的辅助手段。