Ivashkevich A A, Nosa'r V I, Kurbakov L A
Kosm Biol Aviakosm Med. 1989 Sep-Oct;23(5):70-5.
In rats exposed to hypoxia (breathing 11% O2-N2 for 15 min), activity of neutral peptide hydrolases in lungs and serum was measured before and after altitude chamber training. When exposed to normal air breathing, activity of lung neutral peptide hydrolases was markedly higher in Group 1 rats, i.e. those in whom O2 consumption changed insignificantly in response to the hypoxic test, than in Group 2 rats, i.e. those in whom O2 consumption increased in response to the hypoxic test. After altitude chamber training activity of lung and serum neutral peptide hydrolases decreased in Group 1 rats and increased in Group 2 rats. The potential correlation between lung and blood neutral proteolysis is discussed. Its contribution to the biochemical control of oxygen transport via blood rheological properties and vascular tone is considered.
在暴露于低氧环境（呼吸含11%氧气-氮气的混合气体15分钟）的大鼠中，在进行高原舱训练前后测量了肺和血清中中性肽水解酶的活性。当呼吸正常空气时，第1组大鼠（即在低氧试验中氧气消耗量变化不显著的大鼠）肺中性肽水解酶的活性明显高于第2组大鼠（即在低氧试验中氧气消耗量增加的大鼠）。高原舱训练后，第1组大鼠肺和血清中性肽水解酶的活性降低，第2组大鼠则升高。讨论了肺与血液中性蛋白水解之间的潜在相关性。考虑了其对通过血液流变学特性和血管张力进行氧气运输的生化控制的贡献。
