Calderhead R Glen, Kim Won-Serk, Ohshiro Toshio, Trelles Mario A, Vasily David B
Clinique L Dermatology, Goyang, South Korea.
Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul.
Laser Ther. 2015 Dec 30;24(4):277-89. doi: 10.5978/islsm.15-OR-17.
Aggressive, or even minimally aggressive, aesthetic interventions are almost inevitably followed by such events as discomfort, erythema, edema and hematoma formation which could lengthen patient downtime and represent a major problem to the surgeon. Recently, low level light therapy with light-emitting diodes (LED-LLLT) at 830 nm has attracted attention in wound healing indications for its anti-inflammatory effects and control of erythema, edema and bruising.
The wavelength of 830 nm offers deep penetration into living biological tissue, including bone. A new-generation of 830 nm LEDs, based on those developed in the NASA Space Medicine Laboratory, has enabled the construction of planar array-based LED-LLLT systems with clinically useful irradiances. Irradiation with 830 nm energy has been shown in vitro and in vivo to increase the action potential of epidermal and dermal cells significantly. The response of the inflammatory stage cells is enhanced both in terms of function and trophic factor release, and fibroblasts demonstrate superior collagenesis and elastinogenesis.
A growing body of clinical evidence is showing that applying 830 nm LED-LLLT as soon as possible post-procedure, both invasive and noninvasive, successfully hastens the resolution of sequelae associated with patient downtime in addition to significantly speeding up frank wound healing. This article reviews that evidence, and attempts to show that 830 nm LED-LLLT delivers swift resolution of postoperative sequelae, minimizes downtime and enhances patient satisfaction.
积极的,甚至是微创的美学干预几乎不可避免地会引发不适、红斑、水肿和血肿形成等情况,这些可能会延长患者的恢复时间,对外科医生来说是一个重大问题。最近,830纳米的发光二极管低强度光疗法(LED-LLLT)因其抗炎作用以及对红斑、水肿和瘀伤的控制,在伤口愈合适应症方面受到了关注。
830纳米的波长能够深入穿透包括骨骼在内的活体生物组织。基于美国国家航空航天局太空医学实验室开发的新一代830纳米发光二极管,使得构建具有临床可用辐照度的平面阵列式LED-LLLT系统成为可能。体外和体内研究均表明,830纳米能量的照射能显著提高表皮和真皮细胞的动作电位。炎症阶段细胞的反应在功能和营养因子释放方面均得到增强,成纤维细胞表现出卓越的胶原蛋白生成和弹性蛋白生成能力。
越来越多的临床证据表明,在手术后尽快应用830纳米LED-LLLT,无论是侵入性还是非侵入性的,除了能显著加速开放性伤口愈合外,还能成功加速与患者恢复时间相关的后遗症的消退。本文回顾了这些证据,并试图表明830纳米LED-LLLT能迅速消除术后后遗症,将恢复时间减至最短,并提高患者满意度。