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Chondrocyte Apoptosis in Rheumatoid Arthritis: Is Preventive Therapy Possible?

作者信息

Malemud Charles J

机构信息

Department of Medicine, Division of Rheumatic Diseases, Case Western Reserve University, School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106 USA.

出版信息

Immunotherapy (Los Angel). 2015 Dec;1(1). Epub 2015 Oct 31.

Abstract
摘要

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本文引用的文献

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Bioinformatics-Based Identification of MicroRNA-Regulated and Rheumatoid Arthritis-Associated Genes.
PLoS One. 2015 Sep 11;10(9):e0137551. doi: 10.1371/journal.pone.0137551. eCollection 2015.
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miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.
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SF Treg cells transcribing high levels of Bcl-2 and microRNA-21 demonstrate limited apoptosis in RA.
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