Sanaei Dashti Anahita, Ghahremani Pedram, Hashempoor Tayebeh, Karimi Abdollah
Shiraz HIV/AIDS Research Center, Shiraz University of Medical Sciences, Shiraz 7193613311, Iran.
Pediatric Infectious Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gastroenterol Res Pract. 2016;2016:2045697. doi: 10.1155/2016/2045697. Epub 2016 Jan 10.
Background. Acute gastroenteritis is one of the major sources of morbidity and mortality among young children in developed and developing countries. The aim of this study was to determine the prevalence of human adenovirus- (HAdV-) 40 and HAdV-41 in children hospitalized with gastroenteritis in five different health centers of Iran. Methods. In a cross-sectional epidemiological study, we studied 2682 fecal specimens that were collected from children under the age of 5 years in five educational and therapeutic pediatric centers in Iran from February 2012 to February 2013. Samples were tested for HAdV-40 and HAdV-41, using a specific pair of primers in polymerase chain reaction (PCR) method. Results. HAdV-40 and HAdV-41 were detected in 132 (5.18%) of the patients with diarrhea. A significantly higher prevalence of HAdV-40 and HAdV-41 (58.3%) was observed in children under 12 months of age, compared to other age groups. The male to female ratio was 1.7. Conclusion. The results of this study demonstrated that HAdV-40 and HAdV-41 could be considered etiological agents for acute gastroenteritis among children in Iran. The PCR as a rapid test may increase the chance for a relatively mild course of the disease followed by a complete recovery and avoiding administration of unnecessary antibiotics.
背景。急性肠胃炎是发达国家和发展中国家幼儿发病和死亡的主要原因之一。本研究的目的是确定伊朗五个不同健康中心因肠胃炎住院儿童中人类腺病毒-40（HAdV-40）和腺病毒-41（HAdV-41）的流行情况。方法。在一项横断面流行病学研究中，我们研究了2012年2月至2013年2月期间从伊朗五个儿科教育和治疗中心收集的2682份5岁以下儿童的粪便标本。使用聚合酶链反应（PCR）方法中的一对特异性引物对样本进行HAdV-40和HAdV-41检测。结果。在132例（5.18%）腹泻患者中检测到HAdV-40和HAdV-41。与其他年龄组相比，12个月以下儿童中HAdV-40和HAdV-41的患病率显著更高（58.3%）。男女比例为1.7。结论。本研究结果表明，HAdV-40和HAdV-41可被视为伊朗儿童急性肠胃炎的病原体。PCR作为一种快速检测方法，可能会增加疾病病程相对较轻、随后完全康复并避免使用不必要抗生素的机会。
