2006-2011 年巴西肠型和非肠型人腺病毒株的多样性。
Diversity of enteric and non-enteric human adenovirus strains in Brazil, 2006-2011.
机构信息
Enteric Disease Laboratory, Virology Center, Adolfo Lutz Institute, Av. Dr Arnaldo, nº 355, São Paulo, SP, 01246-902, Brazil.
Retrovirology Laboratory, Federal University of São Paulo, São Paulo, Brazil.
出版信息
Arch Virol. 2021 Mar;166(3):897-903. doi: 10.1007/s00705-020-04946-3. Epub 2021 Jan 18.
During 2006-2011, 5035 fecal samples were tested by PCR for human adenovirus (HAdV) and sequenced. HAdV was detected in 198 cases (3.9%), with the highest rate in children ≤ 5 years. Enteric HAdVs were the most prevalent genotypes (78%; 146/187): HAdV-F41 (63.6%; 119/187), HAdV-F40 (12.3%; 23/187), HAdV-A12 (1.6%; 3/187) and HAdV-A31 (0.5%; 1/187). Non-enteric HAdVs were detected in 22% (41/187): HAdV-C1 (8.0%; 15/187), HAdV-C2 (6.9%; 13/187), HAdV-C5 (4.3%; 8/187), HAdV-D8 (1.3%; 2/187), HAdV-B21 (0.5%; 1/187), HAdV-B3 (0.5%; 1/187) and HAdV-C6 (0.5%; 1/187). This 6-year retrospective study points out a high diversity of HAdV types circulating in Brazil and highlights the need to carry out molecular epidemiological studies of HAdV among patients with acute diarrheal infection on a regular basis.
2006 年至 2011 年期间，对 5035 份粪便样本进行了人腺病毒（HAdV）PCR 检测和测序。在 198 例（3.9%）中检测到 HAdV，其中≤5 岁儿童的检出率最高。肠道 HAdV 是最常见的基因型（78%；146/187）：HAdV-F41（63.6%；119/187）、HAdV-F40（12.3%；23/187）、HAdV-A12（1.6%；3/187）和 HAdV-A31（0.5%；1/187）。22%（41/187）检测到非肠道 HAdV：HAdV-C1（8.0%；15/187）、HAdV-C2（6.9%；13/187）、HAdV-C5（4.3%；8/187）、HAdV-D8（1.3%；2/187）、HAdV-B21（0.5%；1/187）、HAdV-B3（0.5%；1/187）和 HAdV-C6（0.5%；1/187）。这项为期 6 年的回顾性研究指出，巴西流行的 HAdV 类型具有高度多样性，强调有必要定期对急性腹泻感染患者的 HAdV 进行分子流行病学研究。
Zotero 插件