Hsu Dur-Zong, Chu Pei-Yi, Jou I-Ming
Department of Orthopedics, National Cheng Kung University Hospital, Tainan, Taiwan.
Department of Orthopedics, National Cheng Kung University Hospital, Tainan, Taiwan.
J Nutr Biochem. 2016 Mar;29:36-40. doi: 10.1016/j.jnutbio.2015.10.007. Epub 2015 Oct 26.
Osteoarthritis (OA) is the most common form of arthritis, affecting approximately 15% of the population. The aim of this study was to evaluate the efficacy of sesame oil in controlling OA pain in rats. Rat joint pain was induced by medial meniscal transection in Sprague-Dawley rats and assessed by using hindlimb weight distribution method. Muscular oxidative stress was assessed by determining lipid peroxidation, reactive oxygen species and circulating antioxidants. Sesame oil significantly decreased joint pain compared with positive control group in a dose-dependent manner. Sesame oil decreased lipid peroxidation in muscle but not in serum. Further, sesame oil significantly decreased muscular superoxide anion and peroxynitrite generations but increased muscular glutathione and glutathione peroxidase levels. Further, sesame oil significantly increased nuclear factor erythroid-2-related factor (Nrf2) expression compared with positive control group. We concluded that daily sesame oil supplement may attenuate early joint pain by inhibiting Nrf2-associated muscular oxidative stress in OA rat model.
骨关节炎（OA）是最常见的关节炎形式，影响着约15%的人口。本研究的目的是评估芝麻油在控制大鼠OA疼痛方面的疗效。通过在Sprague-Dawley大鼠中进行内侧半月板横断来诱导大鼠关节疼痛，并使用后肢重量分布方法进行评估。通过测定脂质过氧化、活性氧和循环抗氧化剂来评估肌肉氧化应激。与阳性对照组相比，芝麻油以剂量依赖的方式显著降低了关节疼痛。芝麻油降低了肌肉中的脂质过氧化，但血清中未降低。此外，芝麻油显著降低了肌肉中超氧阴离子和过氧亚硝酸盐的生成，但提高了肌肉中谷胱甘肽和谷胱甘肽过氧化物酶的水平。此外，与阳性对照组相比，芝麻油显著增加了核因子红细胞2相关因子（Nrf2）的表达。我们得出结论，在OA大鼠模型中，每日补充芝麻油可能通过抑制与Nrf2相关的肌肉氧化应激来减轻早期关节疼痛。
