Materials Genome Institute, Shanghai University, Shanghai 200444, China; Department of Chemistry, Shanghai University, Shanghai 200444, China.
Materials Genome Institute, Shanghai University, Shanghai 200444, China; State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Biosens Bioelectron. 2016 Jun 15;80:601-606. doi: 10.1016/j.bios.2016.02.019. Epub 2016 Feb 13.
Hydrogen peroxide (H2O2) as an important reactive oxygen species (ROS) is reactive and potentially harmful to cells, causing oxidation of lipids, proteins and DNA. Herein, we report a PtW/MoS2 hybrid nanocomposite with ultrasensitive and highly specific response for the detection of H2O2 released from breast cancer 4T1 cells. Upon exposure to 5 nM of H2O2, the electrochemical response is still visible. This PtW/MoS2 hybrid nanocomposite could be facilely synthesized through in-situ growth of PtW nanocrystals on the surface of MoS2 nanosheets. The incorporation of PtW nanocrystals and MoS2 nanosheets in conjunction with each other to form hybrid nanocomposite improves the selective interaction of H2O2 with sensing material surface, and further increases the sensitivity and selectivity of sensor.
过氧化氢（H2O2）作为一种重要的活性氧（ROS），具有反应活性，对细胞潜在有害，可导致脂质、蛋白质和 DNA 氧化。在此，我们报道了一种具有超灵敏和高特异性响应的 PtW/MoS2 杂化纳米复合材料，用于检测乳腺癌 4T1 细胞释放的 H2O2。在暴露于 5 nM 的 H2O2 下，电化学响应仍然可见。PtW/MoS2 杂化纳米复合材料可以通过在 MoS2 纳米片表面原位生长 PtW 纳米晶来简便地合成。PtW 纳米晶和 MoS2 纳米片的结合形成杂化纳米复合材料，改善了 H2O2 与传感材料表面的选择性相互作用，进一步提高了传感器的灵敏度和选择性。
